Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2004148 T-cell Intracytoplasmic Antigen (TIA-1) by Immunohistochemistry T/NK-Cell Lymphomas, Tumor Markers T-cell intracytoplasmic antigen:
  • Reacts with 50-60% of CD8 lymphocytes, 10% of CD4 lymphocytes, monocytes, granulocytes, activated CD4 T-cells, activated NK cells, and con A-activated thymocytes
  • Aids in differentiating T-cell leukemias and lymphomas from B-cell leukemias and lymphomas
2004160 Tartrate-Resistant Acid Phosphatase (TRAP) by Immunohistochemistry Hairy cell leukemia, B-Cell Lymphomas
  • Found in hairy cells, osteoclasts, activated macrophages, and giant cells
  • Useful as a marker for hairy cell leukemia in bone marrow
2004142 TdT by Immunohistochemistry Acute Lymphoblastic Leukemia (ALL), B-cell and T-cell Acute Lymphoblastic Leukemia, Tumor Markers
  • Used in subtyping of blastic leukemias
  • Positive in all Acute Lymphoblastic Leukemia (ALL), except Burkitt's and B-cell FAB L-3
  • Positive in Lymphoblastic crisis of Chromic Myelogenous Leukemia (CML-BC-ALL) and Lymphoblastic Lymphoma
  • Some non-lymphocytic leukemias express positivity, but there is less intensity and greater variability
2010688 TFE3 by Immunohistochemistry
  • Indicated in the clinical diagnosis of malignancy as an aid in the recognition of Xp11 translocation in renal cell carcinoma and alveolar soft-part sarcoma.
  • Also reported in transitional renal cell carcinoma, lung adenocarcinoma, papillary thyroid carcinoma, melanoma, and mesothelioma.
2004145 Thyroglobulin by Immunohistochemistry Thyroid Cancer, Tumor Markers, Thyroid Disease
  • Protein synthesized by the follicular epithelial cells of the thyroid
  • Aids in the localization of thyroglobulin in hyperplastic and neoplastic thyroid and in monitoring of patients after treatment for follicular carcinomas
2004166 Thyroid Transcription Factor (TTF-1) by Immunohistochemistry Thyroid Cancer, Lung Cancer, Tumor Markers, sarcoma, mesothelioma, neuroendrocrine Thyroid transcription factor-1:
  • Expressed in lung and thyroid epithelial cells
  • Present in pulmonary small cell carcinomas, some pulmonary non-small cell carcinomas, papillary carcinomas, follicular carcinomas and goiter, thyroid medullary carcinomas, and thyroid papillary carcinomas
  • Aids in differentiating pulmonary adenocarcinomas from breast carcinomas
2004157 Toxoplasma gondii by Immunohistochemistry Toxoplasma gondii
  • Detects the presence of Toxoplasma gondii in infected tissues