Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2004127 S-100 Protein by Immunohistochemistry Melanoma, Tumor Markers
  • Brain protein composed of S-100a and S-100b
  • Expressed in neural crest (Schwann cells, melanocytes, glial cells), chondrocytes, adipocytes, myoepithelial cells, macrophages, Langerhans cells, and dendritic cells
  • Present in 95% of melanomas (including desmoplastic and spindle cell tumors), 50% of malignant peripheral nerve sheath tumors, clear cell sarcomas, and occasional breast and undifferentiated carcinomas
2004137 Simian Virus 40 (SV-40) by Immunohistochemistry BK Virus, Simian Virus
  • Closely related to BK Virus and JC Virus
  • Used to identify all polymavirus infections due to cross-reactivity between SV-40 and BK Virus and JC Virus.
2006403 Smad4 by Immunohistochemistry
  • May be useful in the diagnosis of pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome
  • The pattern of reactivity is mostly cytoplasmic but sometimes nuclear expression is seen in many cell types with highest expression levels in placenta and gastrointestinal tract
2004130 Smooth Muscle Actin (SMA) by Immunohistochemistry Smooth Muscle Marker
  • Reacts with the alpha-smooth muscle isoform
  • Present in smooth muscle cells of vessels, parenchymes, myoepithelial cells, pericytes, and some stromal cells in the intestine, testis, and ovary
  • Aids in differentiating leiomyosarcoma from rhabdomyosarcoma
2012561 SOX11 by Immunohistochemistry
  • Lymphoma/hematopoietic marker
  • Will stain those cases of Mantle-cell lymphoma that are negative for the cyclin D1 stain, thereby aiding in a more timely diagnosis of MCL
2004139 Synaptophysin by Immunohistochemistry Neuroendocrine Marker, Glucagonoma, Somatostatinoma, VIPoma, Insulinoma, Ewing Sarcoma, Gastrinoma, Pancreatic Neuroendocrine Tumors (NET), Carcinoid Tumors, Brain Tumors, Pancreatic Cancer, Pheochromocytoma, Lung Cancer, Tumor Markers
  • Labels neuroendocrine cells and neurons in the brain, spinal cord, and retina
  • Present in neuroendocrine tumors and neuroendocrine tumors of epithelial type