Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2004064 p16 by Immunohistochemistry Head and Neck Cancer, Cervical Cancer, Bladder Cancer, Ovarian Cancer, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, Tumor Markers, Pancreatic Cancer, Melanoma, prognostic F-12:
  • Negative regulator of the cell cycle
  • Prognostic significance (breast, colon, stomach, lung, and pituitary)
2004067 p21 (Waf1/Cip 1) by Immunohistochemistry Pancreatic Cancer, Melanoma, Bladder Cancer, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Colorectal Cancer, Tumor Markers WAF1/Cip1:
  • Inhibits and blocks cell cycle progression
  • Present in melanomas, pancreatic carcinomas, cervical carcinomas, thymomas, thyroid carcinomas, breast carcinomas, head and neck carcinomas, colon carcinomas, and Hodgkin lymphoma
2010142 P40 by Immunohistochemistry
  • More specific marker than p63 for lung SCC, bladder, breast, prostate, and head and neck cancers.
  • Selectively expressed in lung SCC.
2004076 P504S (AMACR) by Immunohistochemistry Prostate Cancer
  • Prostate
  • α-Methylacyl-CoA Racemase (AMCAR)
  • Specific for prostate adenocarcinomas
  • Detected in two premalignant lesions: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia
2004522 p53 by Immunohistochemistry Tumor marker, Non-small cell lung cancer, lung cancer
  • Tumor suppressor protein; prognostic indicator
2004073 p63 by Immunohistochemistry Bladder Cancer, Lung cancer, small cell lung cancer, neuroendrocrine
  • Differentiates prostatic adenocarcinoma and benign prostatic tissue.
  • Also distinguishes poorly differentiated squamous cell carcinoma from small cell carcinoma or adenocarcinoma.
2004094 Paired Helical Filament -Tau (PHF-Tau) by Immunohistochemistry
  • Tau is abnormally phosphorlated in Alzheimer´s disease
  • Main component in paired helical filaments (PHFs) and neurofibrillary tangles
2004118 Parathyroid Hormone (PTH) by Immunohistochemistry Acromegaly, Parathyroid Cancer, Tumor Markers, adenomas and primary and secondary hyperplasias PTH:
  • Reacts with parathyroid epithelial cells
  • Present in adenomas and primary and secondary hyperplasias
2004082 Pax-5 by Immunohistochemistry Acute Myelogenous Leukemia (AML), B-Cell Lymphomas, Hodgkin lymphomas, Tumor Markers
  • Member of the paired box family
  • B-cell-specific activator protein (BSAP)
  • Expressed in pro-, pre-, and mature B-cells, but not in plasma cells
  • Present in pre B-cell acute lymphoblastic leukemias and classic Hodgkin lymphomas
  • Aids in differential diagnosis of lymphoplasmacytic lymphomas or plasmacytomas
2010787 PAX8 by Immunohistochemistry
  • Expressed in a high percentage of ovarian serous, endometroid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas
  • Important marker of ovarian cancer and a useful marker for the differential diagnosis in lung and neck tumors, or tumors at distant sites where primary lung carcinoma, breast carcinoma, or thyroid carcinoma are possibilities.
2004085 PD-1 by Immunohistochemistry
  • Angioimmunoblastic T-cell lymphomas are the only hematopoietic tumors that are positive for PD1 protein.
  • In tonsil and lymph tissues the protein is expressed on T-cells and some B-cells of the light zone of germinal centers.
2011158 PD-L1 by Immunohistochemistry PD-L1 IHC
2010045 PIN4 Prostate Triple Stain by Immunohistochemistry Prostate Triple Stain:
  • Contains Basal Cell Cocktail (34βE12/p63) and P504s
  • Aids in the identification of prostate carcinoma
  • More sensitive than the individual staining of each antibody in the detection of prostatic basal cells
2004097 Placental Alkaline Phosphatase (PLAP) by Immunohistochemistry Testicular Cancer, Brain Tumors, Tumor Markers, Ovarian Cancer PLAP:
  • Expressed by placenta
  • Present in most germ cell tumors, and breast, lung, stomach, pancreas, and ovarian carcinomas
2004103 Pneumocystis jiroveci by Immunohistochemistry Pneumocystis jiroveci Pneumocystis jiroveci (pneumocystis carinii):
  • Detects presence of Pneumocystis jiroveci in infected tissue and free trophozoites
2004106 Procollagen I by Immunohistochemistry
  • Secreted by fibroblasts into the extracellular matrix, where it is cleaved to form collagen
  • Expression and secretion of procollagen is an important feature of wound-healing and tissue-repair processes to which the desmoplastic stroma of malignancy have sometimes been compared
2004525 Progesterone Receptor (PR) by Immunohistochemistry Tumor Markers, Breast Cancer, Ovarian Cancer
  • Identifies A and B forms of progesterone
  • Predictive of response to hormone therapy for breast carcinoma and endometrial cancer
  • Aids in differentiating endocervical from endometrial adenocarcinomas
2004109 Prolactin by Immunohistochemistry Hypopituitarism, Tumor Markers
  • Produced in the anterior pituitary gland
  • Subclassifies pituitary adenomas
2004112 Prostate Specific Antigen by Immunohistochemistry Prostate Cancer, Tumor Markers Prostate-specific antigen:
  • Expressed by prostatic glandular epithelial cells and periurethral and perianal glands
  • Present in prostatic carcinomas, tumors of the colon, liver, lung, parotid, adrenal, and ovary, and, rarely, in metaplasias of the bladder walls
2004079 Prostatic Acid Phosphatase (PAP) by Immunohistochemistry Prostate Cancer Prostate acid phosphatase:
  • Reacts with prostatic epithelial cells and hyperplastic prostate
  • Present in carcinomas of the prostate and metastatic cells of prostate carcinoma, bladder carcinomas, and carcinoid tumors
2004091 Protein Gene Product (PGP) 9.5 by Immunohistochemistry Glucagonoma, Somatostatinoma, VIPoma, Ewing Sarcoma, Gastrinoma, Pancreatic Neuroendocrine Tumors (NET), Carcinoid Tumors, Pancreatic Cancer, Pheochromocytoma, Tumor Markers, neuronal neoplasis Protein gene product 9.5:
  • Expressed in neurons, neuroendocrine cells, and melanocytes
  • Present in neuronal neoplasias (carcinoid tumors)