Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2003993 Mast Cell Tryptase by Immunohistochemistry Mast Cell Disease
  • Present in secretory granules of mast cells
  • Present with inflammatory diseases
2003996 Melan A by Immunohistochemistry Melanoma, Tumor Markers
  • MART-1 antigen
  • Expressed in melanocytes, steroid-producing cells of the adrenal cortex, ovary, and testis
  • Identifies melanomas, adrenocortical tumors, Leydig tumors of the testis, and Sertoli-Leydig ovarian tumors
2011998 MITF by Immunohistochemistry
  • Used in the identification of melanotic lesions, such as malignant melanoma and melanotic neurofibroma
2004002 Muc-1 by Immunohistochemistry Glandular differentiation marker, Pancreatic, thyroid cancer, biliary, Salivary gland
  • Expressed in mucin-secreting epithelial cells of normal endometrium, kidney, lung, pancreas, and stomach
  • Utilized in the detection of Muc-1 glycoprotein in benign and malignant tumors
2004008 Muc-4 by Immunohistochemistry Colorectal Cancer, Tumor Markers, Pancreatic, thyroid, salivary gland, biliary
  • Stains stomach, colon, and the endothelial cells of small blood vessels and capillaries
  • Strong positive staining in colon polyps, colon carcinoma, and gastric adenocarcinoma
  • Positive staining also demonstrated in lung adenocarcinoma and ovarian mucinous adenocarcinoma
2004011 Muscle-Specific Actin (MSA) by Immunohistochemistry Sarcoma, leiomyomas, leiomyosarcomas, rhabdomyosarcomas, some pleomorphic liposarcomas, glomus tumors, desmoid tumors
  • Present in skeletal, cardiac, smooth muscle, and myoepithelial cells
  • Identifies soft tissue tumors with muscle differentiation (leiomyomas, leiomyosarcomas, and rhabdomyosarcomas), some pleomorphic liposarcomas, the majority of glomus tumors, occasional desmoid tumors, and myofibroblasts in some lesions
2004014 Myeloperoxidase (MPO) by Immunohistochemistry Myelodysplastic Syndrome (MDS), Acute Myelogenous Leukemia (AML), Tumor Markers MPO:
  • Reacts with myeloperoxidase from granulocytes
  • Aids in differentiating lymphoid leukemias from myeloid leukemias
  • Identifies granulocytic sarcomas
2004017 Myogenin (Myf4) by Immunohistochemistry Sarcoma, Tumor Markers, leiomyosarcomas, rhabdomyosarcomas
  • Expressed early in skeletal muscle differentiation.
  • Is a sensitive and specific marker for rhabdomyosarcoma.
  • Is more specific than desmin and muscle-specific actin and more sensitive than myoglobin.
2004031 Myoglobin by Immunohistochemistry Sarcoma, Tumor Markers, rhabdomyosarcomas
  • Oxygen binding protein
  • Expressed by striated muscle (cardiac, skeletal)
  • Present in rhabdomyosarcoma and other tumors with skeletal muscle differentiation
2004034 Myosin by Immunohistochemistry Sarcoma, Tumor Markers, rhabdomyosarcomas
  • Contractile protein
  • Expressed in smooth muscle (non-sarcomeric) and skeletal muscle (sarcomeric) forms
  • Aids in muscle differentiation