Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2005857 IDH1R132H Mutation by Immunohistochemistry Glial tumors, astrocytomas , oligodendrogliomas, glioblastomas
  • Distinguishes primary from secondary Glioblastoma multiform (GBM)
  • IDH1 mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors
  • Allows the highly sensitive and specific discrimination of various tumors, such as astrocytoma from primary glioblastomas or diffuse astrocytoma grade II from pilocytic astrocytoma or ependymoma
2003957 Immunoglobulin A (IgA) by Immunohistochemistry
  • Alpha chains of Ig
2003960 Immunoglobulin D (IgD) by Immunohistochemistry
  • Delta chains of IgD
2003963 Immunoglobulin G (IgG) by Immunohistochemistry
  • Gamma chains of IgG
2005844 Immunoglobulin G4 by Immunohistochemistry
  • IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. It is important to recognize this entity and differentiate it from such mimics as lymphoma.
  • Immunohistochemical analysis in the cases of IgG4-related sclerosing disease exhibits significantly more IgG4 positive plasma cells in affected tissues. Clinical manifestations are apparent in the pancreas, bile duct, gallbladder, lacrimal gland, salivary gland, retroperitoneum, kidney, lung, breast thyroid, and prostate.
2003966 Immunoglobulin M (IgM) by Immunohistochemistry
  • Mu chains of IgM
2003969 Inhibin by Immunohistochemistry Brain Tumors, Ovarian Cancer
  • Expressed in Sertoli cells, granulosa cells, and prostate, brain, and adrenal cells
  • Present in sex-cord stromal tumors (including Sertoli cell tumors), adrenocortical tumors, placental and gestational trophoblastic lesions, granular cell tumors of gallbladder and extrahepatic bile ducts, and some carcinomas
2003448 INI1 (BAF47) by Immunohistochemistry Head and Neck Cancer, Sarcoma
  • Indicative of a tumor suppressor role
  • Heterozygous tumors in the soft tissues of the head and neck
2003975 MUM1/IRF4 by Immunohistochemistry B-Cell Lymphomas, Hodgkin lymphoma, Tumor Markers
  • Transcription factor required for B- and T-cell development
  • Expressed in a subset of diffuse large B-cell lymphomas and used in cell of origin classification
  • Aids in the differential diagnosis of PEL among other lymphomas involving the serous body cavities