Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2003860 Hairy Cell Leukemia, DBA.44 by Immunohistochemistry B-Cell Lymphomas
  • Developed against the B-cell antigen
  • Aids in identifying Hairy cell leukemia (particularly "hairy" cytoplasmic processes), some follicular center cell lymphomas, high grade B-cell lymphomas, splenic lymphomas with villous lymphocytes
2003914 HBME-1 (Mesothelial Cell) by Immunohistochemistry Mesothelioma, Thyroid Cancer Anti-mesothelial cell:
  • Has been demonstrated to immunostain the membrane and cytoplasm of normal plural and peritoneal mesothelial cells and of neoplastic epithelial mesothelioma cells.
  • Although both the membrane and cytoplasm of epithelial mesothelioma cells stain positive, the thick membrane staining pattern is found to be a more diagnostically useful marker of malignant mesothelioma.
2003941 Helicobacter pylori by Immunohistochemistry Gastric adenocarcinoma, gastric B-cell lymphoma persistent dyspepsia;duodenal ulcer, gastric MALT, early gastric cancer, gastritis
  • Reacts with antigens of the H. pylori organism
2003923 Hepatocyte Specific Antigen (HSA) by Immunohistochemistry Hepatocellular Carcinoma Hep Par-1:
  • Expressed in hepatocytes
  • Differentiates hepatocellular carcinomas and metastatic carcinomas
  • Differential diagnosis of hepatocellular carcinomas, cholangiocarcinomas, and hepatoblastomas
2003932 Herpes Virus 8 by Immunohistochemistry Kaposi Sarcoma, B-Cell Lymphomas, B- and T-Cell Markers Lymphoma, Castleman disease, Primary Effusion Lymphomas, Tumor Markers Human herpes virus type 8 (latent nuclearantigen):
  • Aids in identifying multicentric Castleman disease, angioimmunoblastic lymphadenopathies, and Kaposi sarcoma
2003935 Melanoma Antibody, HMB45 by Immunohistochemistry Melanoma, Tumor Markers, HMB45 Melanoma-specific antigen:
  • Expressed in junctional cells, blue nevus cells, and fetal and neonatal melanocytes
  • Reacts with the majority of melanomas and other tumors with melanoma/melanocytic differentiation, including melanotic schwannoma clear cell sarcoma
3000101 HSV Herpes Simplex Virus (HSV) Types I/II by Immunohistochemistry Herpes Simplex Virus (HSV)
  • Reacts with antigens common to HSV types 1 and 2; reacts with all the major glycoproteins present in the viral envelope
  • HSV I/II by IHC will aid in identifying tissue infected with the herpes simplex virus
2003920 Human Chorionic Gonadotropin (Beta-hCG) by Immunohistochemistry Trophoblastic, germ cell, lung, melanoma, gastrointestinal, ovarian, testicular cancer hCG:
  • Expressed on placental trophoblasts
  • Aids in identifying trophoblastic germ cell tumor
2003938 Human Placental Lactogen (HPL) by Immunohistochemistry Gestational Trophoblastic Disease, Products of Conception HPL:
  • Reacts with placental syncytrotrophoblastic cells
  • Identifies placental site trophoblastic tumors and exaggerated placental sites