Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2003869 E-Cadherin by Immunohistochemistry Mesothelioma, Breast Cancer, Tumor Markers Cellular adhesion molecule:
  • Loss associated with invasive carcinoma
  • Differentiates LCIS from DCIS in indeterminate breast carcinoma
  • Reduced expression in invasive bladder cancer and ductal carcinoma
  • No expression in lobular carcinoma and LCIS
2003872 Epithelial Membrane Antigen (EMA) by Immunohistochemistry Adenocarcinoma, anaplastic large cell lymphomas, epitheloid sarcomas, Pagets’ disease, plasmacytomas, Pancreatic tumors, Tumor Markers Epithelial membrane antigen:
  • Prognostic
  • Expressed by almost all glandular and ductal epithelial cells including breast and pancreas, activated T-cells, monocytes, some B-cells, follicular dendritic cells, and perineurial cells
  • Aids in identifying most adenocarcinomas, anaplastic large cell lymphomas, epithelioid sarcomas, meningiomas, some mesotheliomas, myelomas, Paget disease, plasmacytomas, squamous cell tumors, and metastatic carcinomas
  • Associated with invasion in pancreatic tumors
2003875 Epithelial-related Antigen, MOC-31 by Immunohistochemistry Mesothelioma, Head and Neck Cancer, Lung Cancer adenocarcinomas, squamous cell carcinomas, adenomas, small cell lung cancers, carcinoids, adenocystic carcinomas, and carcinosarcomas Epithelial related antigen (MOC-31):
  • Aids in identifying adenocarcinomas, squamous cell carcinomas, adenomas, small cell lung cancers, carcinoids, adenocystic carcinomas, and carcinosarcomas
2007332 ERBB2 (HER2)(HercepTest) by Immunohistochemistry HERCEP IHC
  • Predicts a patient’s response to Herceptin Therapy
See Test Code 0049174 for HercepTest with Interpretation.
2012555 ERG by Immunohistochemistry
  • Prostate marker
  • May be used to aid in the identification of prostate adenocarcinomas through the detection of truncated ERG
2004516 Estrogen Receptor (ER) by Immunohistochemistry Ovarian Cancer, Breast Cancer, Tumor Markers Estrogen receptor-alpha:
  • Prognostic for breast cancer
  • Predictive for response of breast cancers to hormonal therapy
  • Differentiates endocervical from endometrial adenocarcinomas
2004055 Ewing Sarcoma (O13) by Immunohistochemistry Ewing Sarcoma, Sarcoma, PNET
  • MIC2 gene products
  • Glycoprotein HBA 71 antigen
  • Aids in identifying primitive peripheral neuroectodermal tumors, peripheral neuroepitheliomas, Ewing sarcoma and lymphoblastic lymphoma