Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2003857 D2-40 by Immunohistochemistry Mesothelioma, Brain Tumors
  • High sensitivity and specificity for lymphatic endothelium
  • Can be used as a reliable lymphatic endothelial cell marker in the evaluation of lymphatic involvement in tumors
2003863 Desmin by Immunohistochemistry Smooth Muscle, Reactive Mesothelial cells, leiomyosarcomas, myogenic sarcomas, rhabdomyosarcoma, PNET, neuroblastoma, GIST, gastrointestinal stromal tumor, Tumor Markers
  • Intermediate filament present in smooth and striated muscle
  • Expressed in reactive mesothelial cells, myoblasts, myofibroblasts (variable), endometrial stroma, and smooth muscle cells
  • Aids in idenitifying smooth muscle tumors (leiomyosarcomas), myogenic sarcomas, striated muscle tumors (rhabdomyosarcoma), PNET, neuroblastomas, and intra-abdominal desmoplastic small round cell tumors
2010168 DOG1 by Immunohistochemistry
  • Shown to be highly specific and sensitive in the diagnosis of GIST
  • Approximately 4–15% of GIST will stain weakly or be negative for CD117 by IHC; in the vast majority of these cases, DOG1 is expressed by IHC.