Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2008652 c-MET by Immunohistochemistry
  • Tumors derived from c-Met expressing epithelia are usually positive; these include colorectal carcinomas, gastric adenocarcinomas, and non-small cell lung carcinomas
  • In gastric cancer and non-small cell lung carcinoma, it has been determined that c-MET drives the cancer
  • It has also been found that c-MET is a resistance pathway in lung cancer for EGFR inhibitors
  • This antibody may be used to aid in the identification of normal and neoplastic c-MET expressing cells. The pattern of reactivity is cytoplasmic/membranous
2008317 C-MYC by Immunohistochemistry
  • c-MYC expression has been described in a variety of cancers including breast cancer, prostate cancer, lymphoma, lung and colon cancers
  • The c-MYC antibody may be used to characterize lymphomas
  • The pattern of reactivity is nuclear
2003475 C4D by Immunohistochemistry
  • Deposits in peritubular capillary might distinguish between Acute Humoral Rejection (AHR) and Acute Cellular Rejection (ACR).
  • AHR: deposits prominently and diffusely in the peritubular capillaries, intense staining has been seen in a widespread, uniform distribution
2003481 Calcitonin by Immunohistochemistry Medullary Thyroid Cancer, Tumor Markers, Endocrine/Adrenal Cancer, Head and Neck Cancer, Thyroid medullary carcinomas
  • Thyroid parafollicular cells (C-cells)
  • Thyroid medullary carcinomas
2003484 Caldesmon by Immunohistochemistry Gastrointestinal Stromal Tumors, GIST, endometrial, stromal, smooth muscle tumors, Tumor Markers
  • High molecular weight isoform is H-caldesmon
  • Calcium-, calmodulin-, tropomyosin-, and actin-binding protein
  • Regulates smooth muscle contraction
  • Aids in identifying angioleiomyomas, glomus tumors, GIST, some endometrial stromal tumors, and uterine smooth muscle tumors (benign or malignant)
  • Differentiates uterine smooth muscle (usually positive) and endometrial stromal differentiation (usually negative)
2003487 Calponin by Immunohistochemistry
  • Can be used to characterize the differentiation process of mammary myoepithelial cells in the developing mammary glad, investigate the nature of myoepithelial cells and to study the development of human smooth muscle cells.
  • High expression might be used as an additional marker of vascular smooth muscle cells, myopithelial cells in normal and benign human mammary gland, and certain stromal myofibroblasts.
2003490 Calretinin by Immunohistochemistry Mesothelioma, Ovarian Cancer, Tumor Markers
  • Calcium-binding protein
  • Mesothelial cells: 89% sensitive, 90% specific for differentiating mesotheliomas from lung adenocarcinomas
  • Aids in identifying mesothelial hyperplasia and epithelioid mesotheliomas
2003824 Carcinoembryonic Antigen, Monoclonal (CEA M) by Immunohistochemistry Mesothelioma, Ovarian Cancer, Colorectal Cancer, Tumor Markers, Cervical Cancer Carcinoembryonic antigen:
  • Specific marker for colon carcinoma
  • Associated with other cancers: breast, stomach, and lung (see CEA polycolonal)
2003827 Carcinoembryonic Antigen, Polyclonal (CEA P) by Immunohistochemistry Hepatocellular Carcinoma, canallicular marker, Pancreatic Cancer, Ovarian Cancer, Lung Cancer, Colorectal Cancer, Tumor Markers CD56e; biliary glycoprotein 1:
  • Reacts with CEA and CEA-like proteins
  • Normal colon: small intestinal crypts and apical surfaces of epithelial cells, small intestinal goblet cell mucin (not intracytoplasmic)
  • Breast: some epithelial cell membranes expressed
  • Liver: biliary tract, hepatocytes are positive
  • Lung adenocarcinomas or mesotheliomas: 85% sensitive, 96% specific for lung adenocarcinoma, diffuse cytoplasmic staining with membrane enhancement
  • Hepatocellular or non-hepatocellular carcinomas: canalicular pattern has 50-90% sensitivity for hepatocellular carcinoma and greater than 95% specificity
  • Present also with lung adenocarcinoma, medullary thyroid carcinoma, colonic adenocarcinoma, pancreatic adenocarcinoma, and hepatocellular carcinoma
2003523 CD10 (CALLA) by Immunohistochemistry Acute Lymphoblastic Leukemia (ALL), Follicular lymphoma, Burkitt lymphoma, Diffuse large B-cell lymphoma, B-Cell Lymphomas, Tumor Markers
  • Common acute lymphoblastic leukemia antigen (CALLA)
  • Aids in identifying lymphoblastic lymphoma, Burkitt lymphoma, follicular lymphoma, and CML
  • Aids in differential diagnosis of small B-cell lymphomas and subtyping of lymphoblastic leukemias
2003806 CD117 (c-Kit) by Immunohistochemistry Gastrointestinal Stromal Tumors (GIST), Lung Cancer, Breast Cancer, Melanoma, Mast Cell Disease, Germ Cell Tumor of Testes and Ovary, Brain Tumors, Myelodysplastic Syndromes, Acute Myeloid Leukemia, (AML), Myeloproliferative Neoplasms (MPN), Tumor Markers
  • Proto-oncogene
  • Inhibitor of apoptotic cell death
  • Aids in identifying small and large cell lung carcinomas, GIST, AML, CML (in blast crisis), breast carcinomas, glioblastomas and melanomas
2003809 CD123 by Immunohistochemistry
  • A marker of dendric cell precursors: is expressed by plasmactoid monocytes, dendric cells, and plasmacytoid dendritic cells.
2003812 CD138 (Syndecan-1) by Immunohistochemistry Plasma Cell Dyscrasias, B-Cell Lymphomas, Tumor Markers
  • Transmembrane heparin sulphate glycoprotein
  • Expressed by normal lymphoid cells, IgG plasma cells, Pre B-cells and immature B-cells
  • Co-receptor for differentiation growth factors
  • Differentiates squamous cell carcinomas, postgerminal center B-cells, and plasma cells
  • Expressed in plasma cells of CLL, plasmacytoid lymphomas, and myelomas
2003526 CD14 by Immunohistochemistry Acute Myelogenous Leukemia, Chronic Myelomonocytic Leukemia, Tumor Markers
  • Acts as a co-receptor for the detection of bacterial lipolysaccharide (LPS).
  • Expressed on cells of myelo-monocytic llineage, including monocytes, macrophages and Langerhan's cells.
2003529 CD15, Leu M1 by Immunohistochemistry Hodgkin Lymphoma, Acute Myelogenous Leukemia, Mesothelioma
  • Hapten X
  • Present in Reed-Sternberg cells, 90% granulocytes, 30-60% monocytes
  • Absent from lymphocytes
  • Expressed by some non-Hodgkin lymphomas, mycosis fungoides and some leukemias
2003815 CD163 by Immunohistochemistry
  • Is restricted in its expression to the monocytic/macrophage lineage.
  • Is present on all circulating monocytes and most tissue macrophages except those found in mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhan’s cells.
2005114 CD19 by Immunohistochemistry Acute Lymphoblastic Leukemia, Tumor Markers, B-Cell Lymphomas CD19:
  • CD19 is to be used in a panel of antibodies to aid in the characterization of B-cell malignancies. The pattern or reactivity is membranous.
  • In normal tissues, the CD19 (clone BT51E) detects protein expressed on the membrane of cells of the B-cell lineage. Staining is seen in the mantle zones and germinal centers of tonsil and tissue infiltrating B-lymphocytes.
  • CD19 is detected in hematological malignancies including: 95% of B-cell lymphomas including small lymphocytic lymphoma, chronic lymphocytic lymphoma, mantle cell lymphoma, follicular lymphoma, Burkitt lymphoma, marginal zone lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, and lymphoblastic lymphoma; 75% of B-cell leukemias including small lymphocytic leukemia, chronic lymphocytic leukemia and Hairy cell leukemia.
2003502 CD1a by Immunohistochemistry Langerhan cell histiocytosis, T-ALL
  • Non-polymorphic MHC class I-related cell surface glycoprotein
  • Expressed by interdigitating reticulum cells, cortical thymocytes, thymomas, langerhans cells and Langerhans histiocytosis cells (histiocytosis X)
  • Aids in identifying some T-cell lymphomas and leukemias
2003505 CD2 by Immunohistochemistry T-cell lymphomas, Mast Cell Disease, Sézary Syndrome, Tumor Markers
  • Mediates adhesion of activated T-cells and thymocytes with antigen-presenting and target cells
  • Expressed by T-lymphocytes and cortical thymocytes
  • Aids in identifying natural killer cells and most malignant cells of T-cell origin
2003532 CD20, L26 by Immunohistochemistry B-Cell Lymphomas, Plasma cell dyscrasias, Tumor Markers
  • Expressed on B-cell precursors and mature B-cells, but lost following differentiation into plasma cells
  • B-lymphocytes: germinal center cells, mantle zone lymphocytes, and interfollicular lymphocytes, but not T-cells, plasma cells, or histiocytes
  • Aids in identifying common acute lymphoblastic leukemia, pre-B acute lymphoblastic leukemia, CLL, prolymphocytic leukemia, hairy cell leukemia, lymphoma cell leukemia, B-cell lymphomas, including Burkitt, Waldenstrom, and immunoblastic B-cell
  • May show some membrane staining of Reed-Sternberg cells in Hodgkin lymphoma
2012844 CD200 by Immunohistochemistry
  • Primarily aids the distinction between CLL/SLL and mantle cell lymphoma where CD200 is usually positive in CLL/SLL and negative in mantle cell lymphoma.
  • CD200 is also positive in other B-cell lymphoproliferative disorders.
2003535 CD21 (Dendritic Cell) by Immunohistochemistry T-Cell Lymphomas, B-Cell Lymphomas, follicular dendritic cells, follicular dendritic sarcoma
  • C3D receptor, CR2, and EBV receptor
  • Expressed by follicular dendritic cells, mature B-cells, some types of epithelial cells, reactive hyperplasia, and plasma cells
  • Low expression on T-cell ALL cells, subset of normal thymocytes and mature T-cells, lymphocytes in the mantle zone, sinus lining cells, and monocytoid B-cells
  • Aids in identifying B-cell CLL, follicular lymphoma, low-grade MALT-type B-cell lymphoma, primary salivary gland and gastric lymphoma, T-cell and histiocyte-rich B-cell lymphoma, angioimmunoblastic T-cell lymphoma, nodular lymphocyte-predominant Hodgkin lymphoma, follicular dendritic sarcoma and some Reed-Sternberg cells not expressing other B- or T-cell-associated markers.
2003541 CD23 by Immunohistochemistry Chronic Lymphocytic Leukemia
  • Expressed by activated B-lymphocytes, activated macrophages, and a portion of follicular dendritic cells
  • Aids in differentiating small lymphocytic lymphoma (+) and mantle cell lymphoma (-)
2003544 CD25 by Immunohistochemistry Mast Cell Disease, Myeloproliferative Neoplasms (MPN), Hairy cell leukemia, Sezary syndrome
  • Mediates helper, suppressor, and cytotoxic functions
  • Expressed on T-cells, HTLV-1-transformed T- and B-cells, EVB-transformed B-cells, myeloid precursors, and oligodendrocytes
  • Aids in study of inflammatory and malignant conditions
2003508 CD3 by Immunohistochemistry T-cell lymphomas, T-cell leukemias, Tumor Markers
  • Binds to the non-glycosylated epsilon chain of CD3 complex
  • Present in T-lymphocytes, thymocytes/early thymocytes
  • Expressed on normal and neoplastic T-cells
2003547 CD30 (Ki-1) by Immunohistochemistry Hodgkin lymphoma, T-cell lymphoma, B-Cell Lymphomas, Tumor Markers, solitary fibrous tumor, sarcoma
  • Ki-1 positive lymphoma
  • Ber-H2
  • Expressed by activated B- and T-lymphocytes, Reed-Sternberg cells
  • Aids in identifying Hodgkin lymphoma, lymphomatoid papulosis, anaplastic large cell lymphoma, some peripheral pleomorphic T-cell lymphomas (both HTLV-1 positive and negative) including those of angioimmunoblastic type and Lennert type and embryonal carcinoma
2003550 CD31 by Immunohistochemistry Vascular neoplasms
  • Platelet-endothelial cell adhesion molecule
  • Expressed by endothelial cells
  • Glycoprotein in platelets
  • Aids in evaluating vascularization in normal and neoplastic tissue and demonstrating endothelial cellderived tumors
2003553 CD33 by Immunohistochemistry Acute Myeloid Leukemia (AML), Tumor Markers
2003556 CD34, QBEnd/10 by Immunohistochemistry B-ALL, T-ALL, Acute myelogenous leukemia, MDS, Tumor Markers
  • Human progenitor cell antigen
  • Present in immature hematopoietic cells and vascular endothelial cells
  • Expressed by some acute myeloid leukemias, undifferentiated leukemias, and acute lymphoblastic leukemias
2003559 CD35 by Immunohistochemistry Sarcoma
  • Mediates neutrophil and monocte phagocytosis of particles coated with C3b and or C4b
  • Shows strong staining pattern on follicular dendritic cells
  • Aids in characterization of histocytic/dendritic cell neoplasms and follicular dendritic cell sarcomas
2003511 CD4 by Immunohistochemistry Sézary Syndrome, T-Cell Lymphomas, Tumor Markers
  • Present on a subset of helper/inducer T-cells, thymocytes, and at a lower level on monocytes
  • Aids in identifying cutaneous T-cell lymphoma, including mycosis fungoides and HTLV-1-associated adult T-cell leukemia and lymphoma
2003565 CD42b by Immunohistochemistry Acute myelogenous leukemia, megakaryocytes
  • Platelet glycoprotein Ib
  • Expressed on platelets and megakaryocytes in bone marrow
  • Aids in phenotyping megakaryoblastic leukemias
  • Absence of CD42b on platelets may indicate Bernard-Soulier syndrome
2003568 CD43, L60 (Leu 22) by Immunohistochemistry T/NK-Cell Lymphomas, B-Cell Lymphomas
  • Expressed on T-lymphocytes, B-lymphocytes, and granulocytes
  • Aids in identifying cells of lymphoid lineage and T-cell lymphomas, and mantle cell lymphomas
2003574 CD45 by Immunohistochemistry Non-Hodgkin lymphomas, Hodgkin Lymphomas, Tumor Markers Leukocyte common antigen:
  • Expressed on the majority of leukocytes
  • Aids in differentiating lymphoid from non-lymphoid neoplasms
2003514 CD5 by Immunohistochemistry T-Cell Lymphomas, B-Cell Lymphomas, Tumor Markers
  • Expressed in T-lymphocytes, thymocytes and subset of B-lymphocytes in lymph nodes
  • Aids in identifying T-cell leukemias, most B-cell chronic lymphocytic leukemias (B-CLL) and mantle cell lymphomas/T- and B-cell lymphomas
2003586 CD52 (CAMPATH-1) by Immunohistochemistry B-cell lymphomas, B-cell leukemias, T-cell leukemias
  • Expressed by lymphocytes, monocytes, eosinophils, thymocytes, and macrophages
  • Expressed by most lymphoid-derived malignancies
  • Variable expression on myeloma cell
2003589 CD56 (NCAM) by Immunohistochemistry Brain Tumors, Sarcoma , Rhabdomyosarcomas, T/NK-Cell Lymphomas, Plasma Cell Dyscrasias, Tumor Markers, Lung Cancer Neural cell adhesion molecule (NCAM):
  • Expressed on natural killer cells and most neuroectodermal tissues
  • Retinoblastoma, medulloblastoma, astrocytoma, neuroblastoma, and rhabdomyosarcoma
2003592 CD57 by Immunohistochemistry T/NK-Cell Lymphomas, Tumor Markers Leu-7, HNK1:
  • Expressed by a subset of natural killer cells and some T-lymphocytes
  • Reacts with myelin-associated glycoprotein in neuroectodermal tissue
  • Aids in identifying small cell lung carcinoma, NK lymphocyte-mediated cytotoxicity, AIDS and AIDS-related complex (ARC), NK and T-cell subset tumors and neural tissue neoplasms
2003595 CD61 (Platelet Glycoprotein IIIA) by Immunohistochemistry Acute myelogenous leukemia, megakaryocytes Platelet glycoprotein IIIa:
  • Expressed on platelets and megakaryocytes
  • Specific for cells showing megakaryoblastic differentiation
  • Aids in identifying megakaryocytic/megakaryoblastic leukemias
2003598 CD68, KP1 by Immunohistochemistry Acute Myeloid Leukemia (AML), Monocytes, Histiocytes, Tumor Markers KP-1:
  • Expressed by Macrophages, blood monocytes, mast cells, and the cell population known as "plasmacytoid T-cells" in reactive lymph nodes
  • Strong to moderate staining in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), true histiocytic neoplasia, melanoma, and some B-cell neoplasms (usually small lymphocytic lymphoma [SLL]) and weak staining in hairy cell leukemia
  • Weak staining in hairy cell leukemia
2003517 CD7 by Immunohistochemistry Sézary Syndrome, T/NK-Cell Lymphomas, Tumor Markers
  • Earliest T-cell-specific antigen to be expressed in lymphocytes
  • Present in thymocytes , most peripheral T-lymphocyte, most natural killer cells
  • Aids in identifying T-cell lymphomas and leukemias of T-cell origin
2003800 CD79A by Immunohistochemistry Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML), B-Cell Lymphomas, Tumor Markers
  • Expressed on pre B-cells until plasma cell stage
  • Found as intracellular component in plasma cells
  • Aids in identifying acute leukemia of precursor B-cell type (common ALL), B-cell lymphomas and some myelomas
2003520 CD8 by Immunohistochemistry T-Cell Lymphomas, Tumor Markers
  • Expressed on a cytotoxic/suppressor subset of T-lymphocyte natural killer cells, thymocytes, and on a subpopulation of null cells
  • Aids in identifying T-cell lymphomas/leukemias
2005534 CDK4 by Immunohistochemistry Sarcoma, liposarcoma
2003821 CDX2 by Immunohistochemistry Intestinal-type sinonasal adenocarcinoma, Colorectal Cancer, Tumor Markers, Lung Cancer
  • Exclusively marks nuclei of colonic epithelial cells and colorectal cancers
  • May be involved in the regulation of proliferation and differentiation in intestinal epithelial cells
  • May be used identifying metastatic colon carcinoma
2003830 Chromogranin A by Immunohistochemistry Neuroendocrine Tumors (NET), Carcinoid Tumors, Medullary Thyroid Cancer, Tumor Markers, Paraganglioma, Carotid body tumor, Olfactory neuroblastoma, pituitary adenomas, islet cell tumors, phaeochromocytomas, medullary thyroid carcinomas, Merkel cell tumors, and carcinoids
  • Expressed in neuronal cells and in secretory granules of endocrine cells: parathyroid gland, adrenal medulla, anterior pituitary gland, islet cells of the pancreas, and C-cells of the thyroid
  • Aids in identifying neuroendocrine tumors: pituitary adenomas, islet cell tumors, phaeochromocytomas, medullary thyroid carcinomas, Merkel cell tumors, and carcinoids
2003839 Collagen IV by Immunohistochemistry Alport Syndrome Renal disease, chronic kidney disease, hematuria, alport
  • Reacts with basement membranes in kidney, skin, striated and smooth muscle, spleen, lymph node, lung, placenta, and tendon
2013260 Comprehensive Muscle Biopsy Workup
2013261 Comprehensive Nerve Biopsy Workup
2008622 CXCL13 by Immunohistochemistry B-lymphocyte chemoattractant / B-Cell attracting chemokine-1 (BLC/BCA-1),
  • CXC chemokine family controlling the organization of B cells within follicles of lymphoid tissues such as spleen, lymph nodes and Peyer’s patches.
  • In T-lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T-cell.
  • Useful marker in the diagnosis of Angioimmunoblastic T-cell lymphoma, when used in a panel can differentiate it from other proliferative T-cell lymphoma.
2003842 Cyclin D1, SP4 by Immunohistochemistry Head and Neck Cancer, Tumor Markers, Mantle cell lymphoma, B-Cell Lymphomas
  • B-cell lymphoma-1
  • Mantle cell lymphoma, various carcinomas (strong staining in carcinomas), multiple myelomas, some parathyroid adenomas, and parathyroid carcinomas
2003845 Cytokeratin 19 (CK 19) by Immunohistochemistry Thyroid Cancer, Tumor Markers CK 19:
  • Reacts with a large number of epithelial cell types, including many ductal and glandular epithelia
  • Aides in identification of many benign and malignant epithelial lesions
2003848 Cytokeratin 20 (CK 20) by Immunohistochemistry Tumor Markers, Bladder Cancer, Hereditary Nonpolyposis Colorectal Cancer, HNPCC, Lung Cancer, Colorectal Cancer, Multiple Carcinomas , Merkel Cell, adenomas, gallbladder, bile duct, gastrointestinal adenocarcinoma, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, transitional cell carcinoma, Pancreatic carcinoma, cholangiocarcinoma, Mesothelioma Cytokeratin 20:
  • Expressed in intestinal epithelium, gastric foveolar epithelium, some endocrine cells of the upper portions of the pyloric glands, urethelium, and Merkel cells in epidermis
  • Aids in identifying colorectal carcinoma, adenomas of the gallbladder and bile ducts, ductal cell adenocarcinomas of the pancreas, mucinous ovarian tumors, transitional cell carcinomas, and Merkel cell carcinomas of the skin
  • Gastrointestinal adenocarcinomas express CK20 to a lesser degree
2003851 Cytokeratin 5,6 (CK 5,6) by Immunohistochemistry Mesothelioma, Bladder Cancer, Prostate Cancer (PSA), Lung Cancer, Tumor Markers Cytokeratins 5 and 6:
  • Stratified squamous epithelial cytokeratin
  • Aids in diagnosing low differentiated pavement epithelium carcinoma, adenocarcinoma, and mesothelioma
  • Differentiates epithelial mesotheliomas (positive-cytoplasmic staining with perinuclear enhancement) from lung adenocarcinoma (89% sensitive, 95% specific)
2003854 Cytokeratin 7 (CK 7) by Immunohistochemistry Gastrinoma, Mesothelioma, Bladder Cancer, Ovarian Cancer, Lung Cancer, Tumor Markers, Multiple Carcinomas, Breast Cancer Cytokeratin 7:
  • Reacts with most glandular and transitional epithelia: breast, lung, bladder, female genital tract (endometrium, fallopian tube), gastrointestinal tract (gallbladder, hepatic ducts, pancreatic ducts), urinary tract, and bile duct
  • Present with subtypes of ovarian, pulmonary, and breast adenocarcinomas, transitional cell carcinomas, tumors of female genital tract (endometrium, fallopian tube), urothelial carcinomas, breast carcinomas, and lung carcinomas
2003493 Cytokeratin 8,18 Low Molecular Weight (CAM 5.2) by Immunohistochemistry Carcinoid Tumors, Hepatocellular Carcinoma, Renal Cell, Rhabdoid tumors, Neuroendocrine, Pancreatic Cancer, Pheochromocytoma, Melanoma, Tumor Markers, Multiple Carcinomas, Colon Cancer, Gastrointestinal Cancer
  • Cytokeratin 8/18 , low molecular weight cytokeratin
  • Hepatocellular and renal cell carcinomas
  • Aids in identifying neuroendocrine carcinoma, melanomas (3%), nuclear inclusions of rhabdoid tumors (composed of tangled intermediate filaments made up of CK8 and vimentin), and mutations associated with idiopathic cirrhosis and chronic hepatitis
2003833 Cytomegalovirus (CMV) by Immunohistochemistry Cytomegalovirus Cytomegalovirus:
  • Reacts with the delayed and early DNA-binding protein p52
  • Does not crossreact with other herpesviruses or adenoviruses