Immunohistochemistry Stains

The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day. The available stains are listed under the Stain and Return Immunohistochemistry tab. If interpretation is needed, please order a consultation.

To order a surgical pathology consultation, please use test code 2013263 Consultation, Surgical Pathology or 2013258 Consultation, Hematopathology. For more information, call (801)581-2507. Please include pertinent clinical history and surgical pathology report.

The Immunohistochemistry Laboratory has a menu of immunohistochemistry tests for which we will provide interpretation by one of our ARUP faculty pathologists. A list of these tests can be found under the Immunohistochemistry Tests tab. The ARUP Immunohistochemistry Laboratory is an NSABP-approved laboratory for the testing of breast markers.
All A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Test # Test Name Test Keywords Test Description
2003442 B Cell Specific Octamer Binding Protein-1 (BOB-1) by Immunohistochemistry B-Cell Lymphomas, Tumor Markers B-cell Oct-binding protein 1; OBF-1:
  • Expressed in spleen and peripheral blood leukocytes, Reed-Sternberg cells, B-cells, and germinal centers
  • Aids in differentiating Hodgkin lymphomas and B-cell lymphomas
2004513 BCL-2 by Immunohistochemistry Follicular lymphoma, Diffuse large B-cell lymphoma, B-Cell Lymphomas B-cell lymphoma-2:
  • Proto-oncogene
  • Over expression increases life span in B-cells
  • Aids in identifying colorectal adenomas, carcinomas
  • Distinguishes follicular lymphoma from reactive follicles
2003457 BCL-6 by Immunohistochemistry B-Cell Lymphomas, Tumor Markers
  • Transcription factor important in germinal center formation
  • Aids in identifying large cell lymphomas, Burkitt lymphoma, and Hodgkin lymphoma (nodular, lymphocyte predominant)
2003463 Anti-Human Epithelial Antigen, Ber-EP4 by Immunohistochemistry Mesothelioma, Lung Cancer, mammary Paget disease, lung adenocarcinomas, trichoepitheliomas, dermatofibromas, basal cell carcinoma, Lung cancer, mesothelioma
  • Epithelial cell membrane glycoprotein
  • Differentiates mesothelial from epithelial cells
  • Aids in identifying mammary Paget disease, lung adenocarcinomas, trichoepitheliomas, dermatofibromas, basal cell carcinomas, and other carcinomas
2003454 Beta-Catenin-1 by Immunohistochemistry Solid-pseudopapillary Neoplasm of Pancreas, Desmoid-type Fibromatosis, Ovarian Cancer, Tumor Markers, Stain and return service only type
  • Binds to cytoplasmic region of e-cadherin molecule
  • Plays a role in cell adhesion, signal transmission, and actin cytoskeleton anchoring
  • Aids in identifying skin, liver, ovary, brain, prostate, and some breast cancers, as well as endometrial, ovarian, and colon carcinomas
2003466 BF-1 by Immunohistochemistry T/NK-Cell Lymphomas, Tumor Markers Beta framework 1; BF-1:
  • Recognizes T-cell receptor (TCR) beta subunit
  • Aids in characterizing alpha-beta T-cell receptors from T-cell clones or polyclonal populations of T-cells
  • Aids in diagnosing T-cell lineage neoplasms
2003472 Breast 2 (GCDFP-15) by Immunohistochemistry Tumor Markers, Mammary carcinoma, Extramammary Pagets disease
  • Gross cystic disease fluid protein-15
  • Produced by cells with apocrine function
  • Differentiation marker for mammary carcinomas
  • Extramammary Paget disease
2003445 Breast Carcinoma b72.3 by Immunohistochemistry Mesothelioma, Lung Cancer, Tumor Markers, Adenocarcinoma, Breast carcinoma Tumor-associated glycoprotein (TAG.72):
  • Recognizes tumor-associated oncofetal antigen
  • Aids in identifying adenocarcinomas and breast carcinomas