Paraneoplastic Neurologic Syndromes

Testing at ARUP Laboratories

Paraneoplastic neurological syndromes (PNS) are diseases that occur due to the remote effects of tumors (usually malignant). The most common tumors associated with PNS include small cell lung cancer (SCLC), thymoma, neuroblastoma, ovarian, breast, testicular, and Hodgkin lymphoma. Researchers believe PNS is caused by cancerfighting abilities of the immune system, in particular antibodies and specific white blood cells, known as T- cells. Instead of attacking only the cancer cells, these immune agents also attack the normal cells of the nervous system and cause neurological disorders.