Pain Management Screen Panel Comparisons
There are multiple methods of drug screening: rapid point-of-care cup, lab immunoassays, and high-resolution screen by time-of-flight (TOF) mass spectrometry. The cutoff values for each drug in each of the screens are listed in the table below. Urine screen by lab immunoassays includes sample validity testing by creatinine.
|
ARUP Drug Screen Cup Kit #49204 |
Drug Screen 9 Panel 0090453, and 9A (Alcohol) Panel 0090454 |
Drug Screen 9 Panel, positive screen will reflex to confirmation |
Drug Panel by TOF High-Resolution Screen, +53 analytes 2003254 |
|
|---|---|---|---|---|
| Specimen Type | Urine | Urine | Serum/Plasma | Serum/Plasma |
| Methodology | Point-of-care IA | IA, Enz | IA | LC-MS/TOF |
| Turn-around time of screen | 5 min | 1–2 days | 1–4 days | 1–4 days |
Drug / Drug Class: Screen Cutoff Values |
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| Amphetamine (AMP) | 500 ng/mL | 300 ng/mL | 30 ng/mL | 20 ng/mL |
| Barbiturates | 150 ng/mL | 200 ng/mL | 75 ng/mL | 75-500 ng/mL |
| Benzodiazepines | 100 ng/mL | 200 ng/mL | 75 ng/mL | 25-75 ng/mL |
| Buprenorphine | 5 ng/mL | |||
| Cocaine | 50 ng/mL | 150 ng/mL | 30 ng/mL | 20 ng/mL |
| Codeine | included in OPI | Included in OPI | Included in OPI | 10 ng/mL |
| Fentanyl | 1 ng/mL | |||
| Hydrocodone | included in OPI | Included in OPI | Included in OPI | 10 ng/mL |
| Marijuana (THC) | 15 ng/mL | 20 ng/mL | 30 ng/mL | 60 ng/mL |
| MDMA (ecstasy) | 600 ng/mL | 500 ng/mL | Included in Methamphetamine | 20 ng/mL |
| Meperidine | 5 ng/mL | |||
| Methadone | 100 ng/mL | 150 ng/mL | 40 ng/mL | 25 ng/mL |
| Methamphetamine | 500 ng/mL | Included in AMP | 30 ng/mL | 20 ng/mL |
| Morphine | Included in OPI | Included in OPI | Included in OPI | 10 ng/mL |
| Opiates Total (OPI) | 100 ng/mL | 300 ng/mL | 30 ng/mL | N/A |
| Oxycodone | 20 ng/mL | 100 ng/mL | 30 ng/mL | 10 ng/mL |
| Phencyclidine | 15 ng/mL | 25 ng/mL | 15 ng/mL | 10 ng/mL |
| Propoxyphene | 30 ng/mL | 75 ng/mL | 25 ng/mL | |
| Tapentadol | 5 ng/mL | |||
| Tramadol | 5 ng/mL | |||
| Other analytes detected |
Tricyclic antidepressants 500 ng/mL |
[9A] Ethanol 40 mg/dL | + 20 other analytes | |
Option to Reflex to Quantitative Confirmation [see cutoffs of confirmation] |
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| Screen + Positive Results Confirmed by GC-MS or LC-MS/MS | No |
Yes, for 9 panel 0092186;
for 9A (Alcohol) panel 0092187 |
Yes, 0092420 |
No confirmation required unless for quantification. Call ASAP if confirmation is desired. |
| When the “Reflex to Quantitative Confirmation” option is ordered, we will automatically retest the specimen by mass spectrometry for the drug(s) found positive in the screen. Note that confirmation testing will not occur if the screen is negative. If you know, or suspect the patient is taking a specific drug, and wish to have the drug tested quantitatively even if the screen is negative, please order together (1) the “Reflex to Quantitative Confirmation” option for the screen AND (2) the quantitative test for the specific drug. If the screen is positive for that drug, we will automatically cancel the duplicated test. | ||||
Immunoassay:IA; Enzymatic:Enz; Gas chromatography:GC; Liquid chromatography:LC; Mass spectrometry: MS; Tandem mass spectrometry:MS/MS; Time-of-flight mass spectrometry:TOF