Breast Cancer

ARUP’s breast cancer test menu now includes the Prosigna Breast Cancer Prognostic Gene Signature (ARUP test code 2010248), which is FDA 510(k) cleared for node-negative (stage I or II) or node-positive (stage II), hormone receptor-positive (HR+) breast cancer patients, and provides fast and accurate assessment of a patient’s risk of recurrence at 10 years if given endocrine therapy alone. Dr. Philip Bernard, a co-inventor of the test and medical director of molecular oncology diagnostics at ARUP Laboratories, oversees the test and can provide additional consultation through ARUP Client Services. Visit ARUP’s Prosigna page for more information.

Visit the free BRCA Mutation Database for information on BRCA1 and BRCA2 gene mutations and their impact on risk of developing breast cancer, ovarian cancer and certain other cancers.

Test # Test Name Test Keywords Additional Information
2003472 Breast 2 (GCDFP-15) by Immunohistochemistry Tumor Markers, Mammary carcinoma, Extramammary Pagets disease Stain and return service only
2012026 Breast and Ovarian Hereditary Cancer Panel, Sequencing and Deletion/Duplication, 20 Genes BOCAPAN, Breast Cancer, Tumor Markers, FISH, ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, EPCAM, MEN1, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53
2011954 Breast and Ovarian Hereditary Cancer Syndrome (BRCA1 and BRCA2) Sequencing BRCA FGS, BRACA, HBOC
2003445 Breast Carcinoma b72.3 by Immunohistochemistry Mesothelioma, Lung Cancer, Tumor Markers, Adenocarcinoma, Breast carcinoma Stain and return service only
0080392 Cancer Antigen 27.29, Serum Breast Cancer
0080464 Cancer Antigen-Breast (CA 15-3), Serum or Plasma Breast Cancer
2010757 Cancer Panel, Hereditary, Deletion/Duplication, 46 Genes CANCER DD, ALK, APC, BAP1, BMPR1A, CDH1, CDK4, CDKN1B, CDKN2A, EPCAM, FH, FLCN, MAX, MEN1, MET, MLH1, MSH2, MSH6, MUYTH, NF2, PHOX2B, PTEN, RB1, RET, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCB1, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, Lynch syndrome, breast cancer, multiple endocrine neoplasia, melanoma, retinoblastoma, paraganglioma, Li-Fraumeni, familial adenomatous polyposis, Peutz-Jegher, HNPCC, inherited cancer, renal cancer, GI cancer, colorectal cancer
2012032 Cancer Panel, Hereditary, Sequencing and Deletion/Duplication, 47 Genes CANCERPAN, Lynch syndrome, breast cancer, multiple endocrine neoplasia, melanoma, retinoblastoma, paraganglioma, Li-Fraumeni, familial adenomatous polyposis, Peutz-Jegher, HNPCC, inherited cancer, renal cancer, GI cancer, colorectal cancer, NGS cancer panel
2003824 Carcinoembryonic Antigen, Monoclonal (CEA M) by Immunohistochemistry Mesothelioma, Ovarian Cancer, Colorectal Cancer, Tumor Markers, Cervical Cancer Stain and return service only
0080080 Carcinoembryonic Antigen, Serum Breast Cancer, Gastrointestinal Cancer, Genitourinary Cancer, Gynecologic Cancer, Lung Cancer, Tumor Markers
0093399 Circulating Tumor Cell Count Colorectal Cancer, Tumor Markers, mestastatic colorectal carcinoma, mestastic breast cancer, mestastic prostate cancer, prognostic Additional Technical Information
2012769 Cytochrome P450 2C19, CYP2C19 - 9 Variants CYP2C19, Pharmacogenetics (PGx), Schizophrenia, Breast Cancer, breast biomarkers
0051232 Cytochrome P450 2D6 (CYP2D6) 14 Mutations and Gene Duplication CYP 2D6, Tamoxifen, Pharmacogenetics (PGx), Schizophrenia, Breast Cancer, breast biomarkers
2010229 Cytogenomic Molecular Inversion Probe Array, Copy Number and Heterozygosity Assessment - Formalin-Fixed Paraffin-Embedded (FFPE) Tissue FFPE ARRAY, array CGH; aCGH; Array Comparative Genomic Hybridization; Chromosomal Microarray; CMA;  CGH; Microarray; Single-nucleotide-polymorphism (SNP) array; Whole Genome Array; tumor; oncology, formalin-fixed, paraffin-embedded, FFPE; tissue
2000443 Cytology, Fine Needle Aspirate Breast Cancer, mass lesion, malignancy, cancer, infection, lymph node, salivary gland, thyroid
2000623 Cytology, Non-Gynecologic
0095155 DNA Content/Cell Cycle Analysis, Miscellaneous
2003869 E-Cadherin by Immunohistochemistry Mesothelioma, Breast Cancer, Tumor Markers Stain and return service only
2008603 ERBB2 (HER-2/neu) Gene Amplification by FISH, Tissue HER2FISH, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, pathvision, pathvysion
2007785 ERBB2 (HER2/neu) (HercepTest) by Immunohistochemistry, Tissue with Reflex to Dual ISH if 2+
0049390 ERBB2 (HER-2/neu) Gene Amplification by PCR Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu Additional Technical Information
0049178 ERBB2 (HercepTest®) by Immunohistochemistry, Tissue with Reflex to FISH if 2+ Gastric, gastrointestinal cancer, tumor marker, pharmacogenetics, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, Pancreatic Cancer, Gastric Cancer, Barrett’s Esophagus Cancer, Gastroesophageal Junction Cancer
0049174 ERBB2 (HercepTest®) with Interpretation by Immunohistochemistry, Tissue Gastric, gastrointestinal cancer, tumor marker, pharmacogenetics, Breast Cancer, Tumor Markers, FISH, herceptin, HER2, HER-2, neu, HER2/neu, Pancreatic Cancer, Gastric Cancer, Barrett’s Esophagus Cancer, Gastroesophageal Junction Cancer
0049210 Estrogen/Progesterone Receptor with Interpretation by Immunohistochemistry Breast Cancer, Tumor Markers
2004672 HER-2/neu Quantitative by ELISA Ovarian Cancer, Breast Cancer, Tumor Markers
2003978 Keratin 903 (K903) High Molecular Weight by Immunohistochemistry Mesothelioma, Bladder Cancer, Prostate Cancer, Breast Cancer Stain and return service only
2007182 Ki-67 with Interpretation by Immunohistochemistry
0049250 p53 with Interpretation by Immunohistochemistry Brain Tumors, Head and Neck Cancer, Chronic Lymphocytic Leukemia (CLL), Bladder Cancer, Ovarian Cancer, Hereditary Nonpolyposis Colorectal Cancer (HNPCC), Breast Cancer, Colorectal Cancer, Tumor Markers, Tumor suppressor protein, prognostic indicator, Non-small cell lung cancer, lung cancer
2010787 PAX8 by Immunohistochemistry PAX8, combined with organ system-specific markers, can collectively serve as a very useful panel to determine the primary site of micropapillary ovarian carcinomas from invasive carcinomas arising from bladder, lung, and breast.
2008377 Peutz-Jeghers Syndrome (STK11) Deletion/Duplication STK11, STK11 DD, hamartomatous polyps, mucocutaneous hypergigmentation
2008394 Peutz-Jeghers Syndrome (STK11) Sequencing STK11, STK11 FGS, hamartomatous polyps, mucocutaneous hypergigmentation
2008398 Peutz-Jeghers Syndrome (STK11) Sequencing and Deletion/Duplication STK11, STK11 FGA, hamartomatous polyps, mucocutaneous hypergigmentation
2004510 PIK3CA Mutation Detection Tumor Markers, Breast Cancer, Colorectal Cancer, Lung Cancer, Gastrointestinal Cancer, Pancreatic Cancer Additional Technical Information
2004525 Progesterone Receptor (PR) by Immunohistochemistry Tumor Markers, Breast Cancer, Ovarian Cancer Stain and return service only
2010248 Prosigna Breast Cancer Prognostic Gene Signature pam50, pam 50, PAM50, PAM 50, PAM-50
2004115 PTEN by Immunohistochemistry Prostate Cancer, prostate epithelium, breast, ductal epithelium, gastric mucosa, glial cells Stain and return service only
2007991 Solid Tumor Mutation Panel by Next Generation Sequencing Additional Technical Information