ARUP's Laboratory Test Directory

Cytology, ThinPrep® Pap with Reflex to Human Papillomavirus (HPV) DNA Probe, High Risk : 8100212

Mnemonic: TR REPORT

Ordering Recommendation: Order for cervical cancer screening (includes Pap smear interpretation).
Methodology: ThinPrep® 2000 System/Microscopy/Nucleic Acid Probe
Performed: Mon-Fri
Reported: 1-14 days
Specimen Required: Collect: Refer to Cytology, ThinPrep® Pap Test™ Specimen Collection for collection guidelines.

Remarks: This test includes a Cytology, ThinPrep® Pap Test™(ARUP test code 8100211), and an Human Papillomavirus (HPV) DNA Probe, High Risk, ThinPrep® (ARUP test code 0060750) ONLY if the ThinPrep® PapTest™ is interpreted as atypical squamous cells of undetermined significance (ASC-US).

Unacceptable Conditions: Refer to unacceptable conditions for Human Papillomavirus (HPV) DNA Probe, High Risk, ThinPrep® (ARUP test code 0060750) and Cytology, ThinPrep® PapTest™ (ARUP test code 8100211).

Stability (collection to initiation of testing): Ambient: 3 weeks; Refrigerated: 3 weeks; Frozen: Unacceptable
Reference Interval:
High-Risk HPV: Negative
Interpretive Data: Women with atypical squamous cells of undetermined significance (ASC-US) should be managed using a program of either repeat cervical cytology testing, immediate colposcopy, or DNA testing for high-risk types of Human Papillomavirus (HPV).  Testing for HPV DNA is the preferred approach when liquid-based cytology is used for screening.  All women who test positive for high-risk HPV DNA should be referred for colposcopic evaluation.  Women with ASC-US who test negative for high-risk HPV DNA can be followed up with repeat cytologic testing at 12 months (2001 ASCCP Guidelines -JAMA 2002; 287:2120-2129):
A positive high-risk HPV test result indicates that the patient may be infected with one or more of the following HPV genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68, which are associated with cervical cancer and its precursor lesions.  However, cross-reactions with other genotypes may occur.  Results should be correlated with cytologic/histologic findings.
Note: A negative result does not rule out the presence of an HPV genotype absent for the test panel, a low level infection, or specimen sampling error.
CPT Code(s): CPT codes vary based on testing performed If reflexed, add 87621
Cross References: Pap Test (Cytology, ThinPrep® Pap with Reflex to Human Papillomavirus (HPV) DNA Probe, High Risk) , ThinPrep® Reflex to HPV (Cytology, ThinPrep® Pap with Reflex to Human Papillomavirus, High Risk)