ARUP's Laboratory Test Directory
| 8100212: Cytology, ThinPrep® Pap with Reflex to Human Papillomavirus (HPV) DNA Probe, High Risk |
| Test Mnemonic: GPR | |
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Methodology: ThinPrep® 2000 System/Routine Cytopathologic Evaluation/Nucleic Acid Probe
Performed: Mon-Fri Reported: 1-14 days |
| Specimen Required: | |
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Collect: and Transport: Refer to Cytology, ThinPrep® Pap Test™(8100211) Specimen Collection in this section for collection guidelines.
Transport: Submit specimen according to Biological Substance, Category B, shipping guidelines. Pediatric Collection/Transport: Submit specimen according to Biological Substance, Category B, shipping guidelines. Remarks: This test includes a Cytology, ThinPrep® Pap Test™(8100211), and an Human Papillomavirus (HPV) DNA Probe, High Risk, ThinPrep® (0060750) ONLY if the ThinPrep® PapTest™ is interpreted as atypical squamous cells of undetermined significance (ASC-US). Unacceptable Conditions: Refer to unacceptable conditions for Human Papillomavirus (HPV) DNA Probe, High Risk, ThinPrep® (0060750) and Cytology, ThinPrep® PapTest™ (8100211). Stability: Ambient: 3 weeks; Refrigerated: 3 weeks; Frozen: Unacceptable |
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| Reference Interval: |
| High-Risk HPV: Negative |
| Interpretive Data: | |
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Women with atypical squamous cells of undetermined significance (ASC-US) should be managed using a program of either repeat cervical cytology testing, immediate colposcopy, or DNA testing for high-risk types of Human Papillomavirus (HPV). Testing for HPV DNA is the preferred approach when liquid-based cytology is used for screening. All women who test positive for high-risk HPV DNA should be referred for colposcopic evaluation. Women with ASC-US who test negative for high-risk HPV DNA can be followed up with repeat cytologic testing at 12 months (2001 ASCCP Guidelines -JAMA 2002; 287:2120-2129): A positive high-risk HPV test result indicates that the patient may be infected with one or more of the following HPV genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68, which are associated with cervical cancer and its precursor lesions. However, cross-reactions with other genotypes may occur. Results should be correlated with cytologic/histologic findings. |
| Note: | |
| A negative result does not rule out the presence of an HPV genotype absent for the test panel, a low level infection, or specimen sampling error. |
| CPT Code(s): | |
| CPT codes vary based on testing performed. If reflexed to HPV add: 87621 High-risk HPV |