ARUP's Laboratory Test Directory

Drug Detection Panel by High-Resolution Time-of-Flight Mass Spectrometry, Umbilical Cord Tissue : 2006621
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Additional Technical Information
  


Mnemonic: TOF SCR CD

Methodology: Qualitative Liquid Chromatography-Time of Flight Mass Spectrometry
Performed: Mon-Fri
Reported: 1-5 days
Specimen Required: Collect: at least 6 inches of umbilical cord.

Specimen Preparation: Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or an equivalent. Pat the specimen dry and place in container for transport.

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Cords soaking in blood. Tissue that is obviously decomposed.

Stability (collection to initiation of testing): Ambient, 1 week; Refrigerated, 3 weeks; Frozen, 1 year
Reference Interval:
 
Drugs covered and range of cutoff concentrations. Note that some drugs are identified based on the presence of unique drug metabolites not listed below.
Drugs/Drug Classes Range of Cutoff Concentrations
Opioids:
buprenorphine, codeine, fentanyl, heroin (6-acetylmorphine), dihydrocodeine, hydrocodone, hydromorphone, meperidine, methadone, morphine, naloxone, naltrexone, oxycodone, oxymorphone, propoxyphene, tapentadol, tramadol 		1-10 ng/g
Stimulants:
amphetamine, cocaine, methamphetamine, MDMA (Ecstasy), MDEA (Eve), MDA, phentermine 		8 ng/g
Sedatives-hypnotics:
alprazolam, amobarbital, butalbital, clonazepam, diazepam, flunitrazepam, flurazepam,lorazepam, midazolam, nitrazepam, nordiazepam, oxazepam, phenobarbital, secobarbital, temazepam, triazolam, zolpidem 		5-40 ng/g
Phencyclidine (PCP) 4 ng/g

Interpretive Data: Methodology: Qualitative Liquid Chromatography-Time of Flight Mass Spectrometry

Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory.  Glucuronide metabolites are indicated as -G.

For medical purposes only; not valid for forensic use unless testing was performed within Chain of Custody process.
Note: Absolute Minimum:  6 inches
CPT Code(s): 80100 x2 (HCPCS: G0431)
Cross References: Drug Screen, Targeted, Serum or Plasma, Drugs of Abuse Panel, Meconium - Screen with Reflex to Confirmation/Quantitation