ALK Gene Rearrangements in NSCLC for Crizotinib Eligibility by FISH
:2006102
Mnemonic: ALK GENE
Methodology:
Fluorescence in situ Hybridization
Performed:
Varies
Reported:
7-10 days
Specimen Required:
Collect: Tumor tissue.
Specimen Preparation: Formalin fix (10 percent neutral buffered formalin) and paraffin embed tumor tissue. Transport tissue block or 4 unstained, consecutively cut, 5-micron thick sections, mounted on positively charged glass slides. (Min: 4 slides) Protect paraffin block and/or slides from excessive heat.
Storage/Transport Temperature: Room temperature. Also acceptable: Refrigerated.
Remarks: Include surgical pathology report with reason for referral. The laboratory will not reject specimens that arrive without a pathology report but will hold the specimen until this information is received.
Stability (collection to initiation of testing): Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
