ARUP's Laboratory Test Directory

High Avidity Double-Stranded DNA (HA dsDNA) Antibody, IgG : 2005526
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Additional Technical Information
  


Mnemonic: HA DSDNA

Methodology: Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Wed
Reported: 1-8 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Urine or plasma. Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze-thaw cycles)
Reference Interval:
30 IU/mL or less: Negative
31 IU/mL or greater: Positive
Interpretive Data: The high-avidity double-stranded DNA (HA dsDNA) IgG antibody is more specific, although less sensitive, for the diagnosis of systemic lupus erythematosus (SLE) and is more often associated with renal involvement (lupus nephritis) than the low-affinity anti-dsDNA (LA dsDNA) IgG antibody.
CPT Code(s): 86225
Cross References: Farrzyme (High Avidity Double-Stranded DNA (HA dsDNA) Antibody, IgG), HA DNA (High Avidity Double-Stranded DNA (HA dsDNA) Antibody, IgG), HA Native DNA (High Avidity Double-Stranded DNA (HA dsDNA) Antibody, IgG), High Avidity DNA (High Avidity Double-Stranded DNA (HA dsDNA) Antibody, IgG), High Avidity dsDNA (High Avidity Double-Stranded DNA (HA dsDNA) Antibody, IgG), High Avidity Native DNA (High Avidity Double-Stranded DNA (HA dsDNA) Antibody, IgG)