#ExistInterpData>This panel is useful in the initial diagnosis of PNH and was developed according to recently published guidelines (Cytometry B Clin Cytom. 2010 Jul; 78(4):211-30); it includes diagnostic WBC analysis and high-sensitivity RBC analysis. WBC analysis is the most accurate measurement of the PNH clone size with a lower limit of detection of 0.1 percent PNH cells and uses FLAER, CD14, and CD24 as GPI-linked markers with CD15 and CD33 as lineage-specific markers. The high sensitivity RBC analysis has a lower limit of detection of 0.005 percent PNH cells and quantifies Type II and Type III RBC populations when the percentage of PNH RBCs is greater than 1 percent. Glycophorin A is used to gate the RBC population. CD59 is the GPI-linked antigen. Recent RBC transfusions may decrease the percentage of PNH cells. (Cytometry 42:223-33, 2000).
This test also detects minor (0.005-0.999 percent) PNH clone populations found in bone marrow failure disorders.
See Compliance Statement A: www.aruplab.com/CS
||PI-Linked Antigens, RBCs, Monocytes and Granulocytes (Paroxysmal Nocturnal Hemoglobinuria Panel, RBC and WBC)