ARUP's Laboratory Test Directory

Myelin Associated Glycoprotein (MAG) Antibodies, IgM and Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibodies, IgM : 2004412

Mnemonic: MAG/SGPG

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Tue
Reported: 1-8 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Urine. Contaminated, heat-inactivated, hemolyzed, icteric, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval:
Test Number Components Reference Interval
0051285Myelin Associated Glycoprotein (MAG) Antibody, IgM Less than 1000 TU
0051284Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibody, IgM Less than 1.00 IV

Interpretive Data: Detection of IgM antibody against myelin-associated glycoprotein (MAG) suggests active demyelination in peripheral neuropathy. The possibility of myelin-associated glycoprotein (MAG) antibody involvement in a suspected neuropathy may essentially be ruled out if a MAG IgM negative result is obtained. Detection of MAG IgM antibody by ELISA using human MAG (100 kD) antigen is significantly more sensitive and specific than MAG Western blot and IFA assays using primate antigen.

The majority of sulfate-3-glucuronyl paragloboside (SGPG) IgM-positive sera will show reactivity against MAG. Patients who are SGPG IgM positive and MAG IgM negative may have multi-focal motor neuropathy with conduction block.

TU=Titer Units

See Compliance Statement D: www.aruplab.com/CS
CPT Code(s): 83516 x2
Cross References: MAG and SGPG Antibodies (Myelin Associated Glycoprotein (MAG) Antibodies, IgM & Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibodies, IgM) , MAG Antibody Dual ELISA (Myelin Associated Glycoprotein (MAG) Antibodies, IgM & Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibodies, IgM) , MAG Dual Antigen (Myelin Associated Glycoprotein (MAG) Antibodies, IgM & Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibodies, IgM) , Myelin Assoc. Glycoprotein (MAG) Antibody w/Reflex to MAG-SGPG & MAG, EIA (Myelin Associated Glycoprotein (MAG) Antibodies, IgM & Sulfate-3-Glucuronyl Paragloboside (SGPG) Antibodies, IgM)