ARUP's Laboratory Test Directory

Leukocyte Adhesion Deficiency Panel : 2004359

Mnemonic: LAD PAN

Methodology: Semi-Quantitative Flow Cytometry
Performed: Sun-Sat
Reported: 1-3 days
Specimen Required: Collect: Green (sodium or lithium heparin).

Specimen Preparation: Transport 5 mL whole blood. (Min: 1 mL)

Storage/Transport Temperature: Refrigerated.

Remarks: Client must supply a CBC and a differential with the whole blood specimen. The differential must include eosinophil and basophil counts. Specimen must be analyzed within 48 hours of collection.

Unacceptable Conditions: Clotted specimens. Frozen or room temperature specimens. Specimens greater than 48 hours.

Stability (collection to initiation of testing): Ambient: Unacceptable; Refrigerated: 48 hours; Frozen: Unacceptable
Reference Interval:
Effective August 20, 2012
Available Separately Component Reference Interval
No % CD11b 93-100%
No % CD15 91-100%
No % CD18 98-100%

Interpretive Data: The Leukocyte Adhesion Deficiency Panel measures the receptors CD11b, CD15, and CD18 on neutrophils. The percentage of patient neutrophils bearing these receptors is reported. Although these receptors are normally found on neutrophils; values outside of the reference interval may correlate with abnormal neutrophil function. For example, CD18 is decreased or absent in Leukocyte Adhesion Deficiency (LAD) type I and CD15 is decreased or absent in LAD type II.

See Compliance Statement A: www.aruplab.com/CS
CPT Code(s): 86356 x3