ARUP's Laboratory Test Directory

Drug Detection Panel by High-Resolution Time-of-Flight Mass Spectrometry, Serum or Plasma : 2003254
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Additional Technical Information
  


Mnemonic: TOF SCR SP

Methodology: Qualitative Liquid Chromatography-Time of Flight Mass Spectrometry
Performed: Mon-Fri
Reported: 1-4 days
Specimen Required: Collect: Gray (sodium fluoride/potassium oxalate). Also acceptable: Plain red, green (sodium heparin), lavender (EDTA), or pink (K2EDTA).

Specimen Preparation: Remove plasma from cells ASAP or within 2 hours of collection. Transfer 4 mL plasma to an ARUP Standard Transport Tube. (Min: 2 mL) Also acceptable: Serum.

Storage/Transport Temperature: Refrigerated.

Remarks: Cocaine and cocaethylene are more stable in fluoride-preserved plasma than serum.

Unacceptable Conditions: Specimens exposed to repeated freeze/thaw cycles. Separator tubes. Plasma or whole blood collected in lt. blue (sodium citrate).

Stability (collection to initiation of testing): After separation from cells: Ambient: 1 week; Refrigerated: 2 weeks; Frozen: 3 years
Interpretive Data: Methodology: Qualitative Liquid Chromatography-Time-of-Flight Mass Spectrometry

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration must be greater than or equal to the cutoff to be reported as present. If specific drug concentrations are required, contact the laboratory within two weeks of specimen collection to request confirmation and quantification by a second analytical technique.

For medical purposes only; not valid for forensic use.

Drugs covered and range of cutoff concentrations. Note that some drugs are identified based on the presence of unique drug metabolites not listed below.

See Compliance Statement B: www.aruplab.com/CS
 
Drugs/Drug Classes Range of Cutoff Concentrations
Opioids:
buprenorphine, codeine, dihydrocodeine, fentanyl, heroin, hydrocodone, hydromorphone, meperidine, methadone, morphine, naloxone, naltrexone, oxycodone, oxymorphone, propoxyphene, tapentadol, tramadol 		1-25 ng/mL
Stimulants:
amphetamine, cocaine, methamphetamine, MDMA (Ecstasy), MDEA (Eve), MDA, methylphenidate, phentermine 		20-40 ng/mL
Sedative-hypnotics:
alprazolam, amobarbital, butalbital, chlordiazepoxide, clonazepam, diazepam, flurazepam, flunitrazepam, lorazepam, midazolam, nordiazepam, oxazepam, pentobarbital, phenobarbital, secobarbital, temazepam, triazolam, zolpidem 		25-500 ng/mL
Cannabinoids (11-nor-9-carboxy-THC) 60 ng/mL
Phencyclidine (PCP) 10 ng/mL

CPT Code(s): 80100 x2 (HCPCS: G0431).
Cross References: Pain Management (Drug Screen, Targeted, Serum or Plasma)