ARUP's Laboratory Test Directory

Tapentadol and Metabolite - Confirmation/Quantitation - Urine : 2003128

Mnemonic: TAPENTA UR

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed: Tue
Reported: 1-7 days
Specimen Required: Collect: Random urine.

Specimen Preparation: Transfer 2 mL urine with no additives or preservatives to an ARUP Standard Transport Tube. (Min: 1 mL)

Storage/Transport Temperature: Room temperature.

Unacceptable Conditions: Specimens exposed to repeated freeze/thaw cycles.

Stability (collection to initiation of testing): Ambient: 1 week; Refrigerated: 1 month; Frozen: 3 years.
Interpretive Data: Methodology: LC-MS/MS

Drugs Covered: Tapentadol, tapentadol glucuronide, tapentadol-O-sulfate (qualitative only), and n-desmethyltapentadol (qualitative only).

Positive Cutoff:
          Tapentadol                            50 ng/mL
          Tapentadol glucuronide      100 ng/mL
          Tapentadol-O-sulfate          100 ng/mL
          N-desmethyltapentadol      100 ng/mL
                                                 
For medical purposes only; not valid for forensic use.

The presence of metabolite(s) without parent drug is not uncommon and may indicate use over the prior week.

The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, diluted/adulterated urine, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive. Interpretive questions should be directed to the laboratory.
CPT Code(s): 83925
Cross References: Nucynta (Tapentadol and Metabolite, Urine), Pain Management (Tapentadol and Metabolite, Urine), Pain Management, Tapentadol, Quantitative, w/ medMATCH, Urine (Tapentadol and Metabolite, Urine), Pain Management, Tapentadol, Quantitative, w/o medMATCH, Urine (Tapentadol and Metabolite, Urine)