ARUP's Laboratory Test Directory

Human Epididymis Protein 4 (HE4) : 2003020
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Additional Technical Information
  


Mnemonic: HE4

Ordering Recommendation: Not a stand-alone tumor marker for ovarian cancer screening or diagnosis. May be used with CA-125 to monitor epithelial ovarian cancer post therapy if pretreatment levels were elevated. Do not use in mucinous or germ-cell ovarian cancer.
Methodology: Quantitative Enzyme Immunoassay
Performed: Thu, Sun
Reported: 1-8 days
Specimen Required: Collect: Plain red or serum separator tube.

Specimen Preparation: Allow specimen to clot completely at room temperature. Transfer 0.5 mL serum to an ARUP Standard Transport Tube. (Min: 0.1 mL)

Storage/Transport Temperature: Frozen.

Unacceptable Conditions: Hemolyzed or lipemic specimens.

Stability (collection to initiation of testing): Ambient: 4 hours; Refrigerated: 72 hours; Frozen: 60 days
Reference Interval:
0-150 pmol/L
Interpretive Data: HE4 is to be used as an aid in monitoring recurrence of progressive disease in patients with epithelial ovarian cancer.  Serial testing for patient HE4 results should be used in conjunction with other clinical methods for monitoring ovarian cancer. Values obtained with different assay methods should not be used interchangeably.  ARUP uses the Fujirebio Diagnostics, Inc. HE4 enzyme immunometric assay.
CPT Code(s): 86305
Cross References: HE4 (Human Epididymis Protein 4 (HE4)), Human HE4 Antigen (Human Epididymis Protein 4 (HE4)), Ovarian Cancer Monitoring (Human Epididymis Protein 4 (HE4))