ARUP's Laboratory Test Directory

MDM2 Gene Amplification by FISH : 2003016
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Additional Technical Information
  


Mnemonic: MDM2 FISH

Methodology: Fluorescence in situ Hybridization
Performed: Varies
Reported: 4-12 days
Specimen Required: Collect: Tumor tissue.

Specimen Preparation: Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 5 unstained 5 micron slides. (Min: 3 slides) Protect paraffin block from excessive heat. Transport block(s) and/or slide(s) in a tissue transport kit (ARUP supply #47808) available online through eSupply using ARUP Connect™ or contact ARUP Client Services at (800) 522-2787.

Storage/Transport Temperature: Room temperature or refrigerated. Ship in cooled container during summer months.

Remarks: Include surgical pathology report.

Unacceptable Conditions: Frozen specimens. Specimens fixed or processed in alternative fixatives (alcohol, Prefer®) or heavy metal fixatives (B-4 or B-5). No tumor in tissue. Decalcified specimens.

Stability (collection to initiation of testing): Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Reference Interval:
Available Separately Test Name Reference Interval
No MDM2 by FISH Nonamplified: MDM2:SE12 less than 2.0
Amplified: MDM2:SE12 greater than or equal to 2.0
No MDM2:SE12 RATIO By report
No MDM2 per Cells Counted Ratio By report

Interpretive Data: Refer to report.

See Compliance Statement B: www.aruplab.com/CS
CPT Code(s):
88368 x2
Cross References: Well-Differentiated Liposarcoma (MDM2 Gene Amplification by FISH)