ARUP's Laboratory Test Directory

Human Papillomavirus (HPV) Panel by in situ Hybridization, Paraffin : 2002893

Mnemonic: HPVPAN ISH

Ordering Recommendation: Preferred test is HPV High-Risk in situ Hybridization (2002899). Order to detect both low- and high-risk HPV subtypes in formalin-fixed, paraffin-embedded tissue.
Methodology: In situ Hybridization
Performed: Mon-Fri
Reported: 2-5 days
Specimen Required: Collect: Tissue.

Specimen Preparation: Formalin fix (10% neutral buffered formalin) and paraffin-embed tissue. Transport tissue block or 10 unstained 5 micron slides in a tissue transport kit (ARUP supply #47808). Available online through eSupply using ARUP ConnectTM or contact ARUP Client Services at (800) 522-2787. (Min: 5 slides) Protect paraffin block and/or slides from excessive heat.

Storage/Transport Temperature: Room temperature or refrigerated. Ship in cooled container during summer months.

Remarks: Room temperature or refrigerated. Ship in cooled container during summer months.

Unacceptable Conditions: Specimens fixed or processed in alternative fixatives (alcohol, Prefer®) or heavy metal fixatives (B-4 or B-5). Frozen specimens.

Stability (collection to initiation of testing): Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Reference Interval:
Test Number Components Reference Interval
2002896Human Papillomavirus (HPV) Low Risk by in situ Hybridization, Paraffin Negative
2002899Human Papillomavirus (HPV) High Risk in situ Hybridization, Paraffin Negative

Interpretive Data: This test detects: Low-risk HPV (genotypes: 6,11) and high-risk HPV (genotypes: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 66).

A negative result does not rule out the presence of an HPV genotype absent from the test panel, a low level infection, or specimen sampling error.

See Compliance Statement A: www.aruplab.com/CS
CPT Code(s): 88365 x2
Cross References: HPV (Human Papillomavirus (HPV) Panel by in situ Hybridization, Paraffin), HPV Panel ISH (Human Papillomavirus (HPV) Panel by in situ Hybridization, Paraffin), HPVPAN ISH (Human Papillomavirus (HPV) Panel by in situ Hybridization, Paraffin), Human Papillomavirus (Human Papillomavirus (HPV) Panel by in situ Hybridization, Paraffin)