ARUP's Laboratory Test Directory

Lymphoma (Aggressive) Panel by FISH : 2002650
[ image for: Time Sensitive]
Time Sensitive
[ image for: Additional Technical Information]
Additional Technical Information


Mnemonic: FISH ALYMP

Methodology: Fluorescence in situ Hybridization
Performed: Sun-Sat
Reported: 3-10 days
Specimen Required: Collect: Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

Specimen Preparation: Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL)

Storage/Transport Temperature: Room temperature.

Remarks: If cell pellets or dropped cytogenetics slides are submitted, a processing fee will not apply. This test must be ordered using Cytogenetic test request form #43099 or through your ARUP interface.

Unacceptable Conditions: Frozen specimens. Paraffin-embedded specimens. Clotted specimens.

Stability (collection to initiation of testing): Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Reference Interval:
By report
Interpretive Data: Probes included: IGH/BCL2, BCL6 and MYC

This panel is for the identification of double hit lymphoma and triple hit lymphoma, both of which show morphologic features intermediate between diffuse large B-Cell lymphoma and Burkitt Lymphoma. Both are aggressive lymphomas and are characterized by a poor survival rate.

Refer to Statement A under Testing Information at http://www.aruplab.com.
Note: A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth.  The fee will vary based on specimen type. To order probes separately, refer to Chromosome FISH, Interphase (2002298).
CPT Code(s): 88271 x3 DNA probe; 88275 x3 Interphase in situ hybridization 100-300; 88291 Interpretation and report - Additional CPT codes modifiers may be required for procedures performed to test for oncologic or inherited disorders.
Cross References: Chromosome Analysis (Lymphoma (Aggressive) Panel by FISH)