ARUP's Laboratory Test Directory

Pancreatobiliary FISH : 2002461

Mnemonic: PF

Methodology: Fluorescence in situ Hybridization/Computer Assisted Analysis/Microscopy
Performed: Weekly
Reported: 4-12 days
Specimen Required: Collect: Bile or pancreatic duct brushings, biliary stent, fine needle aspirates, or pancreatic juices.

Specimen Preparation: Place specimen in Cytolyt® or PreservCyt® fixative vial. If the specimen is a brushing, submit the brush in the fixative. Label specimen with the patient's first and last name, date of birth, specimen source, medical record number (or other unique identifier), and collection date.

Storage/Transport Temperature: Refrigerated.

Remarks: Completed Cytology request form required.

Unacceptable Conditions: Specimens not collected in Cytolyt® or PreservCyt® fixative.

Stability (collection to initiation of testing): Ambient: Unacceptable; Refrigerated: 72 hours; Frozen: Unacceptable
Reference Interval:
Effective February 19, 2013
Positive ≥ 5 cells with gains of two or more chromosomes are present
Equivocal Tetrasomy Cells present with tetrasomic or near tetrasomic signal patterns
Equivocal Trisomy ≥ 10 cells with gains of a single chromosome, (Trisomy 7 or Trisomy 3)
Negative < 5 abnormal cells are present

Interpretive Data: Refer to report.

See Compliance Statement B: www.aruplab.com/CS
Note: The UroVysion™ Kit is designed to detect aneuploidy for chromosomes 3, 7 and 17via fluorescence in situ hybridization (FISH). Results from this test are intended for use, in conjunction with and not in lieu of current standard diagnostic procedures, as an aid for initial diagnosis of pancreatobiliary carcinoma.
CPT Code(s): 88367 x3; If manual: 88368 x3
Cross References: Bile Duct (Pancreatobiliary FISH), Bile Duct Cancer (Pancreatobiliary FISH), Cholangiocarcinoma (Pancreatobiliary FISH), FISH, Bile Duct (Pancreatobiliary FISH), FISH, Pancreas (Pancreatobiliary FISH), Pancreatic Adenocarcinoma (Pancreatobiliary FISH), Pancreatic Cancer (Pancreatobiliary FISH)