ARUP's Laboratory Test Directory

Myeloproliferative Disorders Panel by FISH : 2002360
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Time Sensitive
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Additional Technical Information


Mnemonic: FISH MPD P

Ordering Recommendation: Limited role in the work-up of myeloproliferative neoplasms in the setting of an otherwise optimal cytogenetic study. Aids in exclusion of cryptic BCR-ABL1 rearrangement in chronic myelogenous leukemia and in the exclusion of a PDGFRA abnormality in cases of neoplastic eosinophilia.
Methodology: Fluorescence in situ Hybridization
Performed: Sun-Sat
Reported: 3-10 days
Specimen Required: Collect: Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).
Other specimen types may be acceptable, contact the Cytogenetics Laboratory for specific specimen collection and transportation instructions.

Specimen Preparation: Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).

Storage/Transport Temperature: Room temperature.

Remarks: If cell pellets or dropped cytogenetics slides are not submitted, a processing fee will apply.
This test must be ordered using Cytogenetic test request form #43099 or through your ARUP interface. Submit the Patient History for Cytogenetics (Chromosome) Studies form with the electronic packing list (available at http://www.aruplab.com/genetics/forms.php).

Unacceptable Conditions: Frozen specimens. Paraffin-embedded specimens. Clotted specimens.

Stability (collection to initiation of testing): Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Reference Interval:
By report
Interpretive Data: Probes included: BCR/ABL, PDGFR-alpha, PDGFR-beta, and, FGFR1.

See Compliance Statement A: www.aruplab.com/CS
Note: A processing fee will be charged if this procedure is canceled, at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow culture growth. The fee will vary based on specimen type.
CPT Code(s): 88271 x4; 88275 x4; 88291
Cross References: Chromosome Analysis (Myeloproliferative Disorders Panel by FISH), MPD (Myeloproliferative Disorders Panel by FISH)