Multiple Myeloma Panel by FISH : ARUP Lab Tests

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Multiple Myeloma Panel by FISH : 2002294

Time Sensitive

Patient History For Cytogenetic (Chromosome) Studies

Mnemonic: FISH MMP

Methodology:	Fluorescence in situ Hybridization
Performed:	Sun-Sat
Reported:	5-14 days
Specimen Required:	Collect: Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin). Specimen Preparation: Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 10 mL whole blood (Min: 2 mL). Storage/Transport Temperature: Room temperature. Unacceptable Conditions: Frozen specimens. Paraffin-embedded specimens. Clotted specimens. Stability (collection to initiation of testing): Ambient: Bone Marrow: 24 hours, Whole Blood: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable

Reference Interval: By report
Interpretive Data:	Refer to Statement A under Testing Information at http://www.aruplab.com.
Note:	Fluorescence in situ hybridization (FISH) panel is performed on CD138+ sorted cells (assuming specimen is sufficient for sorting) for multiple myeloma prognosis-specific genomic abnormalities: CKS1B (1q gain), ASS1 (+9), CCND1/IGH (IGH/CCND1 fusion or +11), IGH rearrangement, PML (+15) and p53 (17p deletion). If IGH is positive and not partnered with CCND1, additional testing will include FGFR3/IGH and MAF/IGH. Additional charges will apply. This test must be ordered using Cytogenetic test request form 43097 or through your ARUP interface. Please submit the Patient History for Cytogenetics (Chromosome) Studies form with the electronic packing list. The form is available on ARUP's Web site, aruplab.com/Testing-Information/consentforms-patienthistory.jsp A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.
CPT Code(s):	88271 x6 DNA Probe each; 88275 x6 Chromosomal in situ hybridization, 100-300, cells each; 88291 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
Cross References:	Chromosome Analysis (Multiple Myeloma Panel by FISH)

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