ARUP's Laboratory Test Directory

Multiple Myeloma Panel by FISH : 2002294
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Time Sensitive
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Additional Technical Information


Mnemonic: FISH MMP

Methodology: Fluorescence in situ Hybridization
Performed: Sun-Sat
Reported: 5-14 days
Specimen Required: Collect: Non-diluted bone marrow collected in a heparinized syringe. Also acceptable: Green (sodium heparin).

Specimen Preparation: Transfer 3 mL bone marrow to a green (sodium heparin) (Min: 1 mL). OR transport 5 mL whole blood (Min: 2 mL).

Storage/Transport Temperature: Room temperature.

Remarks: If cell pellets or dropped cytogenetics slides are not submitted, a processing fee will apply.
This test must be ordered using Cytogenetic test request form #43099 or through ARUP interface. Submit the Patient History for Cytogenetics (Chromosome) Studies form with the electronic packing list (available at http://www.aruplab.com/genetics/forms.php).

Unacceptable Conditions: Frozen specimens. Paraffin-embedded specimens. Clotted specimens.

Stability (collection to initiation of testing): Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Reference Interval:
By report
Interpretive Data:

See Compliance Statement A: www.aruplab.com/CS
Note: Fluorescence in situ hybridization (FISH) panel is performed on CD138+ sorted cells (assuming specimen is sufficient for sorting) for multiple myeloma prognosis-specific genomic abnormalities:  CKS1B (1q gain), ASS1 (+9), CCND1/IGH (IGH/CCND1 fusion or +11), IGH rearrangement, PML (+15) and p53 (17p deletion).  If IGH is positive and not partnered with CCND1, additional testing will include FGFR3/IGH and MAF/IGH.  Additional charges will apply.

This test must be ordered using Cytogenetic test request form 43097 or through your ARUP interface. Please submit the Patient History for Cytogenetics (Chromosome) Studies form with the electronic packing list. The form is available on ARUP's Web site, aruplab.com/Testing-Information/consentforms-patienthistory.jsp

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the specimen integrity is inadequate to allow a complete analysis.
CPT Code(s): 88271 x6; 88275 x6; 88291
Cross References: Chromosome Analysis (Multiple Myeloma Panel by FISH)