ARUP's Laboratory Test Directory

Cryoglobulin, Qualitative, with Reflex to Quantitative IgA, IgG, and IgM : 2002063

Mnemonic: CRYGB QNT

Methodology: Qualitative Cold Precipitation/Quantitative Nephelometry
Performed: Sun-Sat
Reported: 3-5 days
Specimen Required: Patient Prep: Fasting specimen preferred.

Collect: Plain red tube.

Specimen Preparation: 1) Draw approximately 7 mL of blood into a pre-warmed (37 degrees C) plain red tube. Alternatively: draw into a pre-warmed (37 degrees C) syringe and immediately transfer blood to a pre-warmed (37 degrees C) plain red tube. 2) Maintain collected blood at 37 degrees C until clotting is complete (up to 1 hour). 3) Separate serum from cells ASAP. Transfer 3 mL serum to an ARUP Standard Transport Tube. (Min: 1 mL) See Remarks.

Storage/Transport Temperature: Room temperature.

Remarks: Proper collection and transport of specimen is critical to the outcome of the test. Submitting quantities less than 3 mL may affect the sensitivity of the test.

Unacceptable Conditions: Plasma. Refrigerated or frozen specimens. Serum separator tubes (SST or other clot-activating tubes). Grossly hemolyzed or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 1 week; Refrigerated: Unacceptable; Frozen: Unacceptable
Reference Interval:
Test Number Components Reference Interval
0050185Cryoglobulin, Qualitative Negative at 72 hours.
Immunoglobulin A, Cryoprecipitate 0 mg/dL
Immunoglobulin G, Cryoprecipitate 0 mg/dL
Immunoglobulin M, Cryoprecipitate 0 mg/dL

Interpretive Data: The sample is examined daily for the presence or absence of cryoglobulin.

See Compliance Statement B: www.aruplab.com/CS
Note: Cryoglobulins are usually associated with certain plasma cell and lymphoproliferative disorders, but have also been demonstrated in collagen vascular disease, hepatitis C infection, and infections such as infectious mononucleosis and cytomegalovirus disease.

If after three days cryoprecipitate is observed, then quantitative immunoglobulins (IgA, IgG, and IgM) will be added. Additional charges apply.
CPT Code(s): 82595; if reflexed, add 82784 x3