ARUP's Laboratory Test Directory

Inflammatory Bowel Disease Differentiation Extended Profile : 2001608

Mnemonic: IBD PLUS

Methodology: Enzyme-Linked Immunosorbent Assay/Indirect Fluorescent Antibody
Performed: Sun, Tue, Thu
Reported: 1-4 days
Specimen Required: Collect: One 4 mL serum separator tube.

Storage/Transport Temperature: 1.5 mL serum at 2-8°C. (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube.

Remarks: Separate serum from cells ASAP.

Unacceptable Conditions: Severely lipemic, contaminated, heat-inactivated, or hemolyzed specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 2 days; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
 
Test Number Components Reference Interval
0051384Outer Membrane Protein (OMP) IgA Negative: 20.0 Units or less
Equivocal: 20.1-24.9 Units
Positive: 25.0 Units or greater
 Saccharomyces cerevisiae Antibody, IgG  20.0 Units or less: Negative
20.1-24.9 Units: Equivocal
25.0 Units or greater: Positive
 Saccharomyces cerevisiae Antibody, IgA 20.0 Units or less: Negative
20.1-24.9 Units: Equivocal
25.0 Units or greater: Positive
 Anti-Neutrophil Cytoplasmic Antibody, Atypical Pattern < 1:20:  Not significant

Interpretive Data: Saccharomyces cerevisiae IgG antibodies are found in 60-70% of Crohn disease (CD) patients and 10-15% of ulcerative colitis (UC) patients. Saccharomyces cerevisiae IgA antibodies are found in about 35% of CD patients but less than 1% in UC patients. Detection of both Saccharomyces IgG and IgA antibodies in the same serum specimen is highly specific for CD.
CPT Code(s): 83516 OMP; 86671 ASCA IgG; 86671 ASCA IgA; 86255 ANCA; if positive; add 86256 ANCA titer
Cross References: IBD Differentiation Extended Profile
 
 

 

 

 
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