ARUP's Laboratory Test Directory

Neisseria meningitidis Tetravalent Antibodies (Serogroups A, C, W-135 and Y), IgG : 2001603

Mnemonic: NMENING

Ordering Recommendation: Use to assess immunocompetence following Neisseria meningitidis vaccination. To assess suspected immunodeficiency, use pre- and postvaccination serology. Do not use for diagnosis of infection or serotyping.
Methodology: Quantitative Multiplex Bead Assay
Performed: Mon
Reported: 1-8 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature: Refrigerated.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval:
N. meningitidis A, C, W-135 and Y, IgG:
0.9 µg/mL or less: Antibody concentration not protective.
1.0-2.0 µg/mL: Equivocal.
2.1 µg/mL or greater: Antibody to Neisseria meningitidis detected. Suggestive of protection.

Responder status is determined according to the ratio of the one month post-vaccination concentration to pre-vaccination concentration of IgG antibodies to N. meningitidis (Types A, C, Y, and W-135) as follows:

1. If the one month post-vaccination concentration is less than 3.0 µg/mL, the patient is considered to be a non-responder.
2. If the one month post-vaccination concentration is greater than or equal to 3.0 µg/mL, a patient with a ratio of greater than or equal to 4 is a good responder, a ratio of 2-4 is a weak responder, and a ratio of less than 2 is considered a non-responder
Interpretive Data:

See Compliance Statement B: www.aruplab.com/CS
CPT Code(s): 86741 x4
Cross References: Neisseria meningitidis (Neisseria meningitidis Tetravalent Antibodies (Serogroups A, C, W-135 & Y), IgG , Vaccine Resonse (Neisseria meningitidis Tetravalent Antibodies (Serogroups A, C, W-135 & Y), IgG)