ARUP's Laboratory Test Directory

RNA Polymerase III Antibody, IgG : 2001601
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Additional Technical Information
  


Mnemonic: RNA POL 3

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Tue, Thu, Sun
Reported: 1-4 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.2 mL)

Storage/Transport Temperature: Refrigerated.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Reference Interval:
Effective May 21, 2012
19 Units or less:                Negative
20-39 Units:                    Weak Positive                                                                                                                                     
40-80 Units:                    Moderate Positive                                                                                                                       
81 Units or greater:              Strong Positive
Interpretive Data:  Elevated RNA polymerase III IgG antibodies are found primarily in a subset of systemic sclerosis (SSc) patients who are typically negative for anti-centromere and anti-Scl-70 antibodies, and which may be predictive of increased risk for skin involvement and hypertensive renal failure associated with the diffuse cutaneous form of scleroderma.
CPT Code(s): 83516
Cross References: RNA Pol III IgG (RNA Polymerase III Antibody, IgG)