ARUP's Laboratory Test Directory

ssDNA Antibody, IgG : 0099528

Mnemonic: DNA SS

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Tue, Thu, Sat
Reported: 1-4 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum an ARUP Standard Transport Tube. (Min: 0.1 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma. Contaminated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
< 20 EU: Negative
20-25 EU: Borderline positive
> 25 EU: Positive
Note: The ssDNA antibody test detects ssDNA and some dsDNA antibodies.  As a result, patient samples should also be tested for dsDNA antibodies in order to more accurately determine the level of anti-ssDNA antibodies.  By calculating the ratio (ssDNA/dsDNA), a conclusion can be made as to the presence of ssDNA antibodies.  A ratio less than or equal to 1.0 indicates the absence of ssDNA antibodies.  A ratio greater than 1.0 indicates the presence of ssDNA antibodies.
CPT Code(s): 86226
Cross References: Anti-ssDNA Antibody (ssDNA Antibody, IgG), DNA Single Stranded Antibody (ssDNA Antibody, IgG), Single Stranded DNA Antibody (ssDNA Antibody, IgG)