Reference Interval:
Negative: 0-20% modulation
Indeterminate: 21-25% modulation
Positive: 26% or greater modulation
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| Interpretive Data: |
Approximately 85-90% of patients with myasthenia gravis (MG) express antibodies to the acetylcholine receptor (AChR), which can be divided into binding, blocking, and modulating antibodies. Binding antibody can activate complement and lead to loss of AChR. Blocking antibody may impair binding of acetylcholine to the receptor, leading to poor muscle contraction. Modulating antibody causes receptor endocytosis resulting in loss of AChR expression, which correlates most closely with clinical severity of disease. Approximately 10-15% of individuals with confirmed myasthenia gravis have no measurable binding, blocking, or modulating antibodies.
Refer to Statement B under Testing Information at http://www.aruplab.com.
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| CPT Code(s): |
83519
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Cross References: |
Myasthenia Gravis Antibodies (Acetylcholine Receptor Modulating Antibody) |
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