ARUP's Laboratory Test Directory

Thyroid Stimulating Immunoglobulin : 0099430

Mnemonic: TSI

Methodology: Quantitative Bioassay/Quantitative Chemiluminescence
Performed: Mon-Sat
Reported: 2-5 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.7 mL)

Storage/Transport Temperature: Frozen.

Unacceptable Conditions: Plasma.

Stability (collection to initiation of testing): After separation from cells: Ambient: 2 hours; Refrigerated: 6 days; Frozen: 3 months
Reference Interval:
Effective November 7, 2011
 
Negative 110% basal activity or less
Positive 111% basal activity or greater

Interpretive Data: Positive results (111 percent or greater) are consistent with Graves disease but do not always correlate with the presence and severity of hyperthyroidism. Antibodies to the Thyroid Stimulating Hormone Receptor (TSHR) may be stimulating, blocking, or neutral. Stimulating antibodies mimic the action of TSH and cause hyperthyroidism (Graves disease). This test determines the net effect of all TSHR antibody types present in the serum specimen.
Note: An elevated Thyroid Stimulating Hormone (TSH) value above 76 mU/L may produce a weakly positive Thyroid Stimulating Immunoglobulin (TSI) result (111 percent or greater).
CPT Code(s): 84445
Cross References: TSI (Thyroid Stimulating Immunoglobulin)
 
 

 

 

 
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