Clomipramine and Metabolite : ARUP Lab Tests

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Clomipramine and Metabolite : 0099336

Mnemonic: CLOMIP

Methodology:	Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed:	Sun-Sat
Reported:	1-3 days
Specimen Required:	Collect: Plain red. Also acceptable: Lavender (K₂ or K₃EDTA) or pink (K₂EDTA). Specimen Preparation: Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL) Storage/Transport Temperature: Refrigerated. Unacceptable Conditions: Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution). Stability (collection to initiation of testing): After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months

Reference Interval: Therapeutic Range: Total clomipramine and norclomipramine: 220-500 ng/mL Toxic: > 900 ng/mL
Interpretive Data:	Plasma concentrations vary widely among patients. The therapeutic range listed relates to the antidepressant characteristics of the drug. A therapeutic range for treating obsessive-compulsive disorder is not well defined.
CPT Code(s):	80299 x2
Cross References:	Anafranil (Clomipramine & Metabolite), Desmethylclomipramine (Clomipramine & Metabolite), Norclomipramine (Clomipramine & Metabolite)

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