ARUP's Laboratory Test Directory

Liver-Kidney Microsome Antibody, IgG : 0099270

Mnemonic: LIVER-KID

Methodology: Semi-Quantitative Indirect Fluorescent Antibody
Performed: Mon-Sat
Reported: 1-3 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.15 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Severely hemolyzed or lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)

Reference Interval:
Less than 1:20 Normal
Interpretive Data: Liver-Kidney Microsome IgG antibody (anti-LKM), as detected by indirect immunofluorescent antibody (IFA) techniques, may be observed in patients with autoimmune hepatitis type 2 (AIH-2), AIH-2 associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), viral hepatitis C or D, and some forms of drug-induced hepatitis. This IFA does not differentiate among the four types of LKM antibodies (LKM-1, LKM-2, LKM-3, and a fourth type that recognizes CYP1A2 and CYP2A6 antigens). Of these, anti-LKM-1 (cytochrome P450IID6) IgG antibodies are considered specific for AIH-2.

See Compliance Statement D: www.aruplab.com/CS
CPT Code(s): 86376
Cross References: LKM IgG Antibodies (Liver-Kidney Microsome Antibody, IgG)