ARUP's Laboratory Test Directory

0098467: Sirolimus

Test Mnemonic: RAPAMUNE
Methodology: Tandem Mass Spectrometry

Performed: Sun-Sat

Reported: Within 24 hours

Specimen Required:  
Collect: One 3 mL lavender (EDTA) or pink (K2EDTA).

Transport: 3 mL whole blood at 2-8°C.  (Min: 1 mL)

Pediatric Collection/Transport: 0.5 mL whole blood at 2-8°C.

Unacceptable Conditions: Serum, plasma, and specimens ambient longer than 24 hours.

Stability: Ambient: 24 hours; Refrigerated: 1 week; Frozen: 7 months

Reference Interval:
Therapeutic Range: 4.0-12.0 ng/mL

Interpretive Data:
The stated therapeutic range is based on a trough specimen, with the patient in the maintenance phase, and sirolimus in combination with cyclosporine for a kidney transplant.  A range of 12-20 ng/mL has been suggested for liver transplant.  The range may vary with other transplant organs, when used in combination with drugs other than cyclosporine (or sirolimus alone), with the approach of the transplant center, and other factors.



CPT Code(s):
80195

 

 

 
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