#ExistInterpData>A therapeutic range of 4-12 ng/mL is proposed, based on a pre-dose (trough) steady-state specimen, concomitant cyclosporine, for a kidney transplant patient in the maintenance phase of therapy. A range of 12-20 ng/mL has been suggested for liver transplant. The range may vary with other transplant organs, when used in combination with drugs other than cyclosporine (or sirolimus alone), with the approach of the transplant center, and with other factors. Symptoms of toxicity are more likely at predose (trough) concentrations that exceed 25 ng/mL.
||Sirolimus (Rapamune®) whole blood concentrations can be measured by either chromatographic or immunoassay methodologies. These two methodologies are not directly interchangeable and the measured sirolimus whole blood concentration is depended on the type of assay used. References ranges may vary according to the specific immunoassay or LC/MS/MS test used. Generally, immunoassays have been reported to have a positive bias relative to the reference assay, HPLC with detection by tandem mass spectrometry (LC/MS/MS), due to detection of antibody cross-reactivity with sirolimus metabolites.
||Rapamune® (Sirolimus by Tandem Mass Spectrometry)
, Rapamycin (Sirolimus by Tandem Mass Spectrometry)