ARUP's Laboratory Test Directory
| 0097779: Chromosome Analysis, Prenatal FISH |
![[ image for: Time Sensitive]](icon_1.jpg){kind=icon} | Time Sensitive | ![[ image for: Patient History For Cytogenetics (Chromosome) Studies]](icon_20.jpg){kind=icon} | Patient History For Cytogenetics (Chromosome) Studies |
| Test Mnemonic: CHROMFISHP | |
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Methodology: Fluorescence in situ Hybridization
Performed: On request Reported: Varies |
| Specimen Required: | |
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Collect: 30 mL amniotic fluid.
Transport: 30 mL amniotic fluid in sterile centrifuge tubes at 20-25°C. Remarks: It is recommended that FISH be performed in conjunction with routine cytogenetic analysis. (Refer to appropriate Chromosome Analysis test for order instructions). Unacceptable Conditions: Frozen or bloody specimens. Stability: Ambient: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable |
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| Note: | |
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Fluorescence in situ hybridization (FISH) is performed for aneuploidy of chromosomes X, Y, 13, 18, and 21. The FISH analysis does not detect structural chromosome abnormalities, mosaicism, and other numerical chromosome abnormalities (excluding X, Y, 13, 18, and 21). In addition, false-positive or negative results, as well as maternal cell contamination, have been demonstrated in prenatal FISH analysis. The American College of Medical Genetics recommends that irreversible therapeutic action should not be initiated on the basis of FISH results alone. Time of testing will vary depending on sample type or probes ordered. A verbal report will be given to client within 24 to 48 hours of specimen receipt. This test must be ordered using a Cytogenetic test request form 43097 or through your ARUP interface. Please submit the Patient History Form - Chromosome Studies with the Electronic Packing List. The form is available on ARUP's Web site, http://www.aruplab.com/home/consent_forms.jsp. A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the sample integrity is inadequate to allow culture growth. |
| CPT Code(s): | |
| 88271 x5 DNA probe; 88275 Interphase in situ hybridization 100-300 each; 88291 Interpretation and report -Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders. |