ARUP's Laboratory Test Directory

Tissue Transglutaminase Antibody (tTG), IgA : 0097709

Mnemonic: TTG

Methodology: Semi-Quantitative Enzyme-Linked Immunosorbent Assay
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect: Serum separator tube.

Specimen Preparation: Separate serum from cells ASAP or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. (Min: 0.3 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Plasma or other body fluids. Contaminated, hemolyzed, or severely lipemic specimens.

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year (avoid repeated freeze/thaw cycles)
Reference Interval:
19 Units or less: Negative
20-30 Units: Weak Positive
31 Units or greater: Moderate to Strong Positive
Interpretive Data: IgA antibody against human tTG, if detected at a level greater than 19 units, may suggest the possibility of certain gluten sensitive enteropathies such as celiac disease and dermatitis herpetiformis.
Note: The endomysial antigen has been identified as the protein cross-linking enzyme known as tissue transglutaminase. Detection of tissue transglutaminase antibodies is an aid in the diagnosis of certain gluten-sensitive enteropathies, such as celiac disease and dermatitis herpetiformis.  Human tTG antigen is utilized in this assay.
CPT Code(s): 83516
Cross References: Celiac Disease (Tissue Transglutaminase Antibody (tTG), IgA), TG2 IgA (Tissue Transglutaminase Antibody (tTG), IgA), tTG, IGA (Tissue Transglutaminase Antibody (tTG), IgA)
 
 

 

 

 
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