ARUP's Laboratory Test Directory

Cortisol Urine Free by LC-MS/MS : 0097222

Mnemonic: CORT UF

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed: Sun-Sat
Reported: 1-2 days
Specimen Required: Collect: 24-hour or random urine. Refrigerate 24-hour specimen during collection.

Specimen Preparation: Transport one 4 mL aliquot of urine. (Min: 1 mL) Record total volume and collection time interval on transport tube and test request form.

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Room temperature specimens. Acidified specimens or specimens with preservatives.

Stability (collection to initiation of testing): Ambient: Unacceptable; Refrigerated: 2 weeks; Frozen: 6 months
Reference Interval:
Effective August 15, 2011
 
Test Name Female Male
Cortisol (µg/day) 3-8 years: Less than 18 µg/day
9-12 years: Less than 37 µg/day
13-17 years: Less than 56 µg/day
18 years and older: Less than 45 µg/day
3-8 years: Less than 18 µg/day
9-12 years: Less than 37 µg/day
13-17 years: Less than 56 µg/day
18 years and older: Less than 60 µg/day
Cortisol (µg/g crt) Prepubertal: Less than 25 µg/g crt
18 years and older: Less than 24 µg/g crt
Pregnancy: Less than 59 µg/g crt
Prepubertal: Less than 25 µg/g crt
18 years and older: Less than 32 µg/g crt
 

Interpretive Data: Ratios to creatinine may be useful for evaluation when the urine collection is random, other than 24 hours, or the urine volume is less than 400 mL/24 hours.

Low urinary cortisol concentrations may be consistent with adrenal insufficiency.
Note: Reference intervals based on literature from Taylor R.L. et al., Validation of a High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Method for Urine Cortisol and Cortisone. Clinical Chemistry 2002; 48:1511-1519.
CPT Code(s): 82530
Cross References: Urinary Free Cortisol (Cortisol Urine Free by LC-MS/MS)
 
 

 

 

 
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