ARUP's Laboratory Test Directory

DNA Content/Cell Cycle Analysis, Products of Conception : 0093386

Mnemonic: DNA POC

Methodology: Flow Cytometry
Performed: Sun, Tue
Reported: 3-9 days
Specimen Required: Collect: Products of conception tissue.

Storage/Transport Temperature: Paraffin-embedded tissue block with products of conception at 20-25°C.

Remarks: Include H & E stained slide and surgical pathology report. If no normal tissue is included in the block, please supply a control tissue block to be processed in parallel.

Unacceptable Conditions: No tissue remaining on the block. Samples fixed in Bouin's Solution (picric acid), mercuric chloride containing fixatives (e.g. B5, Zenker's solution) or ethanol-based fixatives containing ethylene glycol, acetic acid, and zinc chloride. Samples that have been decalcified.

Stability (collection to initiation of testing): Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Interpretive Data: Flow Cytometry can be used to distinguish between partial and complete hydatidiform moles. Partial moles are usually triploid while complete moles are diploid or tetraploid. (Clinical Medicine: Pathology; 2008: 1; 61-7). Of the 35 cases of histologically apparent partial moles, no complication occurred in those that were triploid. However, 20% of those that were diploid had complications (persistence, metastasis). [Am J Obstet Gynecol; 1987:157; 969-73].

Please refer to Statement B in the Compliance Statements section in the front of the Laboratory Test Directory.
Note: A thin section of each tissue submitted is stained with H & E.  The DNA content is classified as diploid, triploid, tetraploid or aneuploid.  The DNA index is the ratio of the DNA content of abnormal cells compared to normal cells.
CPT Code(s): 88182
Cross References: Products of Conception, DNA Content testing
 
 

 

 

 
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