Chromosome Analysis, Multiple Myeloma Panel by FISH : ARUP Lab Tests

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Chromosome Analysis, Multiple Myeloma Panel by FISH : 0092617

Cytogenetic Test Request Form Recommended

Patient History For Cytogenetics (Chromosome) Studies

Mnemonic: FISH MM

Methodology:	Fluorescence in situ Hybridization
Performed:	On Request
Reported:	Varies
Specimen Required:	Collect: 3 mL non-diluted bone marrow aspirate in a heparinized syringe and transfer into a green (sodium heparin). Also acceptable: whole blood in a 10 mL green (sodium heparin) if blast cells are greater than 20%. Transport: 3 mL bone marrow or 10 mL whole blood at 20-25 (Min: 1 mL bone marrow or 5 mL whole blood) Remarks: It is recommended that all FISH studies be done in conjunction with routine cytogenetic analysis. (Refer to appropriate Chromosome Analysis test for order instructions). If FISH only is requested, please submit a copy of previous cytogenetics report. If cell pellets or dropped cytogenetics slides are not submitted, a processing fee will apply. Unacceptable Conditions: Frozen or clotted specimens. Stability: Ambient: Bone Marrow: 24 hours, Whole Blood: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable

Reference Interval: By report
Interpretive Data:	Please refer to Statement C in the Compliance Statements section in the front of the Laboratory Test Directory.
Note:	Fluorescence in situ hybridization (FISH) panel is performed for multiple myeloma prognosis specific genomic abnormalities as follows: 1. IGH/CCND1, 2. D13S319, 3. IgH, 4. p53 This test must be ordered using a Cytogenetic test request form 43099 or through your ARUP interface. Please submit the Patient History Form - Chromosome Studies with the Electronic Packing list. The form is available on ARUP's Web site, http://www.aruplab.com/home/consent_forms.jsp. A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the sample integrity is inadequate to allow a complete analysis.
CPT Code(s):	88271 x4 DNA Probe Each; 88275 x3 Chromosomal in situ hybridization 100-300 cells each; 88291 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.

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