ARUP's Laboratory Test Directory

0092617: Chromosome Analysis, Multiple Myeloma Panel by FISH

[ image for: Cytogenetic Test Request Form Recommended]
Cytogenetic Test Request Form Recommended
[ image for: Patient History For Cytogenetics (Chromosome) Studies]
Patient History For Cytogenetics (Chromosome) Studies

Test Mnemonic: FISH MM
Methodology: Fluorescence in situ Hybridization

Performed: On Request

Reported: Varies

Specimen Required:  
Collect: 3 mL non-diluted bone marrow aspirate in a heparinized syringe and transfer into a green (sodium heparin).  Also acceptable:  whole blood in a 10 mL green (sodium heparin) if blast cells are greater than 20%.

Transport: 3 mL bone marrow or 10 mL whole blood at 20-25 (Min: 1 mL bone marrow or 5 mL whole blood)

Remarks: It is recommended that all FISH studies be done in conjunction with routine cytogenetic analysis. (Refer to appropriate Chromosome Analysis test for order instructions). If FISH only is requested, please submit a copy of previous cytogenetics report.  If cell pellets or dropped cytogenetics slides are not submitted, a processing fee will apply.

Unacceptable Conditions: Frozen or clotted specimens.

Stability: Ambient: Bone Marrow: 24 hours, Whole Blood: 48 hours; Refrigerated: Unacceptable; Frozen: Unacceptable

Reference Interval:
By report

Interpretive Data:




Counseling and informed consent are recommended for genetic testing. Consent forms are available online at www.aruplab.com.

Please refer to Statement C in the Compliance Statements section in the front of the Laboratory Test Directory.



Note:
Fluorescence in situ hybridization (FISH) panel is performed for multiple myeloma prognosis specific genomic abnormalities as follows:

1. IGH/CCND1, 2. D13S319, 3. IgH, 4. p53

This test must be ordered using a Cytogenetic test request form 43099 or through your ARUP interface.  Please submit the Patient History Form - Chromosome Studies with the Electronic Packing list.  The form is available on ARUP's Web site, http://www.aruplab.com/home/consent_forms.jsp.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the sample integrity is inadequate to allow a complete analysis.

CPT Code(s):
88271 x4 DNA Probe Each; 88275 x3 Chromosomal in situ hybridization 100-300 cells each; 88291 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.
 

 

 

 
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