ARUP's Laboratory Test Directory

0092616: Chromosome Analysis, Chronic Lymphocytic Leukemia (CLL) Panel by FISH

[ image for: Cytogenetics Test Request Form Required]
Cytogenetics Test Request Form Required
[ image for: Patient History For Cytogenetics (Chromosome) Studies]
Patient History For Cytogenetics (Chromosome) Studies

Test Mnemonic: FISH CLL

Methodology: Fluorescence in situ Hybridization

Performed: On request

Reported: Varies

Specimen Required:  
Collect: One 10 mL green (sodium heparin).  Also acceptable:  3 mL of non-diluted bone marrow aspirate collected in a heparinized syringe and transferred into a green (sodium heparin).

Transport: 10 mL whole blood or 3 mL bone marrow at 20-25°C. (Min: 5 mL whole blood or 1 mL bone marrow)

Remarks: It is recommended that all FISH studies be done in conjunction with routine cytogenetic analysis. (Refer to appropriate Chromosome Analysis test for order instructions).  If FISH only is requested, please submit a copy of previous cytogenetics report.  If cell pellets or dropped cytogenetic slides are not submitted, a processing fee will apply.

Unacceptable Conditions: Frozen, clotted, or paraffin-embedded specimens.

Stability: Ambient: Whole Blood: 48 hours, Bone Marrow: 24 hours; Refrigerated: Unacceptable; Frozen: Unacceptable.

Reference Interval:
By report

Note:
Fluorescence in situ Hybridization panel is performed for CLL prognosis specific genomic abnormalities as follows:  ATM, Rb-1, D13S25, Trisomy 12, p53

This test must be ordered using a Cytogenetic test request form 43099 or through your ARUP interface.  Please submit the Patient History Form - Chromosome Studies with the Electronic Packing list.  The form is available on ARUP's Web site, http://www.aruplab.com/home/consent_forms.jsp.

A processing fee will be charged if this procedure is canceled at the client's request, after the test has been set up, or if the sample integrity is inadequate to allow culture growth.

CPT Code(s):
88271 x 5 DNA probe each; 88275 x 4 Chromosomal in situ hybridization 100-300 cells each; 88291 Interpretation and report - Additional CPT code modifiers may be required for procedures performed to test for oncologic or inherited disorders.