ARUP's Laboratory Test Directory

Carbamazepine Epoxide & Total : 0092211

Mnemonic: CARB EPOXT

Methodology: High Performance Liquid Chromatography/Immunoassay
Performed: Mon, Thu
Reported: 1-5 days
Specimen Required: Collect:  One 5 mL plain red.

Transport:  1 mL serum at 2-8°C.  (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube.

Remarks:  Avoid use of separator tubes and gels.

Stability:  After separation from cells: Ambient: 2 days; Refrigerated: 6 days; Frozen: 1 month
Reference Interval:
 
Components Therapeutic Range
Carbamazepine-10, 11 Epoxide Not well established
Total Carbamazepine Therapeutic Range: 4.0-12.0 µg/mL
Toxic Range: Greater than 20.0 µg/mL

Interpretive Data: The 10, 11 epoxide metabolite has anticonvulsant activity similar to the parent drug.  The expected range following chronic therapeutic dose (5.2-20.0 mg/kg) of carbamazepine is 0.5-2.0 µg/mL. 
CPT Code(s): 80156; Carbamazepine, total; 80299 Carbamazepine, Epoxide
 
 

 

 

 
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