ARUP's Laboratory Test Directory

Carbamazepine Epoxide and Total : 0092211

Mnemonic: CARB EPOXT

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry/Quantitative Enzyme Multiplied Immunoassay Technique
Performed: Mon, Thu
Reported: 1-5 days
Specimen Required: Patient Prep: Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect: Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation: Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Stability (collection to initiation of testing): After separation from cells: Ambient: 48 hours; Refrigerated: 6 days; Frozen: 1 month
Reference Interval:
Effective February 19, 2013
Available Separately Components Therapeutic Range
No Carbamazepine-10, 11 Epoxide Not well established
Toxic: Greater than 15.0 µg/mL
No Total Carbamazepine Therapeutic Range: 4.0-12.0 µg/mL
Toxic: Greater than 20.0 µg/mL

Interpretive Data: A proposed therapeutic range is 0.4-4 µg/mL. The metabolite, Carbamazepine-10, 11-Epoxide, has anticonvulsant activity to the parent drug.

See Compliance Statement B: www.aruplab.com/CS
CPT Code(s): 80156; 80299
Cross References: 11 Epoxide (Carbamazepine Epoxide and Total), Atretol (Carbamazepine Epoxide and Total), Biston (Carbamazepine Epoxide and Total), Calepsin (Carbamazepine Epoxide and Total), Carbamazepine - 10,11 Epoxide, Serum or Plasma (Carbamazepine Epoxide and Total), Carbamazepine and Epoxide Metabolite (Carbamazepine Epoxide and Total), Carbamazepine-10 (Carbamazepine Epoxide and Total), Epimaz (Carbamazepine Epoxide and Total), Epitol (Carbamazepine Epoxide and Total), Epitrol (Carbamazepine Epoxide and Total), Equetro (Carbamazepine Epoxide and Total), Finlepsin (Carbamazepine Epoxide and Total), Sirtal (Carbamazepine Epoxide and Total), Tegretol, Metabolite (Carbamazepine Epoxide and Total), Telesmin (Carbamazepine Epoxide and Total)