ARUP's Laboratory Test Directory

0092211: Carbamazepine Epoxide & Total

Test Mnemonic: CARB EPOXT
Methodology: High Performance Liquid Chromatography/Immunoassay

Performed: Mon, Thu

Reported: 1-5 days

Specimen Required:  
Collect: One 5 mL plain red.

Transport: 1 mL serum at 2-8°C.  (Min: 0.5 mL) Submit specimen in an ARUP Standard Transport Tube.

Remarks: Avoid use of separator tubes and gels.

Stability: After separation from cells: Ambient: 2 days; Refrigerated: 6 days; Frozen: 1 month

Reference Interval:
 
Components Therapeutic Range
Carbamazepine-10, 11 Epoxide Not well established
Total Carbamazepine Therapeutic Range: 4.0-12.0 µg/mL
Toxic Range: Greater than 20.0 µg/mL

Interpretive Data:
The 10, 11 epoxide metabolite has anticonvulsant activity similar to the parent drug.  The expected range following chronic therapeutic dose (5.2-20.0 mg/kg) of carbamazepine is 0.5-2.0 µg/mL. 



CPT Code(s):
80156; Carbamazepine, total; 80299 Carbamazepine, Epoxide

 

 

 
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