#ExistInterpDataSet>
| Interpretive Data: |
#ExistInterpData>Refer to report.
See Compliance Statement B: www.aruplab.com/CS
*ExistInterpData>
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*ExistInterpDataSet>
#ExistNote>
| Note: |
CBFB (core binding factor β-chain)-MYH11 (myosin heavy chain 11 gene) fusion transcripts are detected in approximately 10% of de novo acute myelogenous leukemias (AML). One half of these cases belong to AML subtype M4 with abnormal eosinophils (AML-M4Eo). The fusion results from a pericentric inversion on chromosome 16 inv(16)(p13q22) or rarely from the translocation t(16;16)(p13;q22). Based on the breakpoints in the CBFB and MYH11 genes, greater than 95% of analyzed inv(16) cases belong to three types: A (88%), D (5%), and E (5%).
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*ExistNote>
#ExistCPT>
| CPT Code(s): |
81401, G0452
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*ExistCPT>
#ExistCrossReferences>
Cross References: |
inv(16) (CBFB-MYH11, inv(16) by RT-PCR)
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*ExistCrossReferences>
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