Reference Interval:
Therapeutic Range:
| Test Number
| Components
| Therapeutic Range:
| | | CARBAMAZEPINE, TOTAL
| Therapeutic Range: 4.0-12.0 µg/mL
Toxic Range: Greater than 20 µg/mL
| | | Free Carbamazepine | Therapeutic Range: 1.0-3.0 µg/mL
Toxic Range: Greater than 3.8 µg/mL
| | | Percent Free Carbamazepine | 8.0-35.0%
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| Interpretive Data: |
Free carbamazepine may be important to monitor in patients with altered or unpredictable protein binding capacity. Carbamazepine is also subject to drug-drug interactions due to displacement of protein binding and extensive metabolism. Cross-reactivity with metabolites may account for differences in carbamazepine among analytical methods. Calculating percent free attempts to minimize differences in assay cross-reactivity and may be useful in dose optimization.
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| CPT Code(s): |
80156 Carbamazepine, total; 80157 Carbamazepine, free
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