ARUP's Laboratory Test Directory

Desipramine : 0090072

Mnemonic: DESIP HPLC

Methodology: Quantitative Liquid Chromatography-Tandem Mass Spectrometry
Performed: Sun-Sat
Reported: 1-3 days
Specimen Required: Patient Prep: If imipramine has been administered, order Imipramine and Desipramine (ARUP test code 0090157). Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration.

Collect: Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation: Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport Temperature: Refrigerated.

Unacceptable Conditions: Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Stability (collection to initiation of testing): After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months

Reference Interval:
Therapeutic Range:
100-300 ng/mL
Toxic: > 500 ng/mL
Interpretive Data: Toxic concentrations may cause anticholinergic effects, drowsiness and cardiac abnormalities.
CPT Code(s): 80160
Cross References: Norpramine (Desipramine), Norpramine by HPLC (Desipramine), Pertofrane (Desipramine)