ARUP's Laboratory Test Directory

0080440: Oligoclonal Band Profile

Test Mnemonic: OLIGO
Methodology: Isoelectric Focusing/Immunofixation/Nephelometry

Performed: Mon, Wed, Fri

Reported: Between 1 and 4 days

Specimen Required:  
Collect: CSF and one 4 mL SST.

Transport: 1.5 mL CSF and 1 mL serum at 2-8°C. (Min: 0.7 mL CSF and 0.5 mL serum)  Submit serum specimen in an ARUP Standard Transport Tube.

Pediatric Collection/Transport: 0.7 mL CSF and 0.5 mL serum at 2-8°C.

Remarks: Allow serum to clot completely at room temperature.  Separate serum from cells ASAP.  Serum specimen should be drawn within 48 hours of CSF collection. Specimens must be assayed together for interpretation.

Stability: Ambient: 8 hours; Refrigerated: 7 days; Frozen: 1 month

Reference Interval:
 
Test Number Components Reference Interval
0050350Immunoglobulin G, Serum  
 
0- 30 days: 611-1542 mg/dL             
1 month: 241-870 mg/dL                         
2 months: 198-577 mg/dL           
3 months: 169-558 mg/dL                   
4 months: 188-536 mg/dL                         
5 months: 165-781 mg/dL                         
6 months: 206-676 mg/dL                           
7-8 months: 208-868 mg/dL                        		9-11 months: 282-1026 mg/dL
1 year: 331-1164 mg/dL
2 years: 407-1009 mg/dL
3 years: 423-1090 mg/dL
4 years: 444-1187 mg/dL
5-7 years: 608-1229 mg/dL
8-9 years: 584-1509 mg/dL
10 years and older: 768-1632 mg/dL
0050670Immunoglobulin G, CSF 0-6.0 mg/dL
0050200Albumin, CSF 0-35 mg/dL
 Albumin Index0.0-9.0
 CSF IgG/Albumin Ratio0.09-0.25
 IgG Index 0.28-0.66
 CSF Oligoclonal Bands Negative
 Interpretation By report
 CSF IgG Synthesis Rate0.0-8.0 mg/d
0050671Albumin, Serum by Nephelometry 3500-5200 mg/dL
 

Note:
A patient is considered positive for CSF oligoclonal bands if there are two or more bands in the CSF immunoglobulin region that are not present in the serum. In order to confirm local production of oligoclonal IgG in CSF, a matched serum sample is required. Oligoclonal bands present in CSF, but not in serum, indicate central nervous system production. Oligoclonal bands are performed using isoelectric focusing and immunofixation.

CPT Code(s):
83916 Oligoclonal immune (Oligoclonal bands); 82784 IgG, serum; 82784 IgG CSF; 82040 Albumin, serum; 82042 Albumin, CSF